Evidence map›Paper›PMID 27181117›Full record

ReviewParasitology2017

Human infection with Strongyloides stercoralis and other related Strongyloides species.

Thomas B Nutman

Registry-linked trialAbstract readReview
In one paragraph

Review in Parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001645 (Evaluation, Treatment, and Monitoring of Patients With Known or Suspected Parasitic Infection), which is not on this map. Cited by 209 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 6 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00001645 recruitingnot on this map

Evaluation, Treatment, and Monitoring of Patients With Known or Suspected Parasitic Infection

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran1998Enrolled800ConditionsMalaria, Intestinal Worms, GI Protozoa, Echiniococcus
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 6 syntheses or guidelines pooled it, 337 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Morbidity Associated with ChronicThe American journal of tropical medicine and hygiene · 2019
    Pooled it
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Seroprevalence and Associated Factors of Anti-Pathogens (Basel, Switzerland) · 2026
    Article
  18. Article
  19. Article
  20. Article

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Thomas B NutmanLaboratory of Parasitic Diseases,National Institute of Allergy and Infectious Diseases,National Institutes of Health,Building 4 - Room B1-03,4 Center Dr.,Bethesda,MD 20892-0425,USA.
National Institutes of Health · US

Funding

Immunoregulation /Immune Recognition In Filarial/Nonfilarial Parasitic InfectionZIAAI000197 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$23.4M
Clinical And Therapeutic Studies Of Human Filariasis and Related DiseasesZIAAI000439 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$14.8M
Immunoregulation /Recognition In non/filarial InfectionZ01AI000197 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI NUTMAN, THOMAS B. · 1985 to 2008
$3.5M
Intramural NIH HHS Z01 AI000197
6 · The paper itself

Abstract

The majority of the 30-100 million people infected with Strongyloides stercoralis, a soil transmitted intestinal nematode, have subclinical (or asymptomatic) infections. These infections are commonly chronic and longstanding because of the autoinfective process associated with its unique life cycle. A change in immune status can increase parasite numbers, leading to hyperinfection syndrome, dissemination, and death if unrecognized. Corticosteroid use and HTLV-1 infection are most commonly associated with the hyperinfection syndrome. Strongyloides adult parasites reside in the small intestine and induce immune responses both local and systemic that remain poorly characterized. Definitive diagnosis of S. stercoralis infection is based on stool examinations for larvae, but newer diagnostics - including new immunoassays and molecular tests - will assume primacy in the next few years. Although good treatment options exist for infection and control of this infection might be possible, S. stercoralis remains largely neglected.

Indexed as

AnimalsAnthelminticsDiagnostic Tests, RoutineHumansMolecular Diagnostic TechniquesParasitologyPrevalenceStrongyloidesStrongyloidiasisAnthelminticsanthelmintic therapyautoinfectioncorticosteroidshyperinfectionStrongyloides stercoralisStrongyloidiasis

Identifiers

PMID27181117
PMCPMC5563389
OpenAlexW2398099644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.