ArticleNeuron2016
Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Divergence of Melanopsin's Intrinsic Properties and Downstream Actions.bioRxiv : the preprint server for biology · 2026Article
- Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer's-like pathology.Communications biology · 2026Article
- A Clinical Practice Example of Smith-Magenis Syndrome in the Neuropediatric Clinic: Etiology, Clinical Presentation, Diagnostics and Therapeutic Approaches-A Case Report.Children (Basel, Switzerland) · 2026Article
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- Advantages of human opsins in optogenetic visual restoration.Frontiers in neuroscience · 2025Review
- Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.Molecular therapy. Methods & clinical development · 2023Article
- The Multistable Melanopsins of Mammals.Frontiers in ophthalmology · 2023Article
- Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina.Pharmaceutics · 2022Article
- Optogenetic induction of hibernation-like state with modified human Opsin4 in mice.Cell reports methods · 2022Article
- Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina.Communications biology · 2022Article
- Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells.Protein & cell · 2022Review
- A neuropsin-based optogenetic tool for precise control of GScience China. Life sciences · 2022Article
- A systematic comparison of optogenetic approaches to visual restoration.Molecular therapy. Methods & clinical development · 2022Article
- Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish.EMBO reports · 2022Article
- Regulation of PDF receptor signaling controlling daily locomotor rhythms in Drosophila.PLoS genetics · 2022Article
- The incidence of candidate binding sites for β-arrestin in Drosophila neuropeptide GPCRs.PloS one · 2022Article
- Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.Scientific reports · 2021Article
- Melanopsin phototransduction: beyond canonical cascades.The Journal of experimental biology · 2021Review
- Structure and function of the gap junctional network of photoreceptive ganglion cells.Visual neuroscience · 2021Article
- Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions.Cellular and molecular life sciences : CMLS · 2021Review
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7 authors.
Funding
Abstract
Melanopsin photopigment expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs) plays a crucial role in the adaptation of mammals to their ambient light environment through both image-forming and non-image-forming visual responses. The ipRGCs are structurally and functionally distinct from classical rod/cone photoreceptors and have unique properties, including single-photon response, long response latency, photon integration over time, and slow deactivation. We discovered that amino acid sequence features of melanopsin protein contribute to the functional properties of the ipRGCs. Phosphorylation of a cluster of Ser/Thr residues in the C-terminal cytoplasmic region of melanopsin contributes to deactivation, which in turn determines response latency and threshold sensitivity of the ipRGCs. The poorly conserved region distal to the phosphorylation cluster inhibits phosphorylation's functional role, thereby constituting a unique delayed deactivation mechanism. Concerted action of both regions sustains responses to dim light, allows for the integration of light over time, and results in precise signal duration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.