Evidence map›Paper›PMID 27181046›Full record

ArticleMitochondrion2016

Analysis of Mitochondrial haemoglobin in Parkinson's disease brain.

Freya Shephard, Oliver Greville-Heygate, Susan Liddell, Richard Emes, Lisa Chakrabarti

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mitochondrion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Proteomic analysis of the ATP synthase interactome in notothenioids highlights a pathway that inhibits ceruloplasmin production.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  7. Article
  8. In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. ExercisingInternational journal of molecular sciences · 2021
    Article
  10. Review
  11. Gender Differences and Quality of Life in Parkinson's Disease.International journal of environmental research and public health · 2020
    Review
  12. Article
  13. Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Freya ShephardUniversity of Nottingham, Faculty of Medicine, SVMS, Sutton Bonington Campus, LE12 5RD, England, UK.
Oliver Greville-HeygateUniversity of Nottingham, Faculty of Medicine, SVMS, Sutton Bonington Campus, LE12 5RD, England, UK.
Susan LiddellDivision of Animal Sciences, School of Biosciences, Sutton Bonington Campus, LE12 5RD, England, UK.
Richard EmesUniversity of Nottingham, Faculty of Medicine, SVMS, Sutton Bonington Campus, LE12 5RD, England, UK.
Lisa ChakrabartiUniversity of Nottingham, Faculty of Medicine, SVMS, Sutton Bonington Campus, LE12 5RD, England, UK. Electronic address: lisa.chakrabarti@nottingham.ac.uk.
University of Nottingham · GBSutton Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Mitochondrial dysfunction is an early feature of neurodegeneration. We have shown there are mitochondrial haemoglobin changes with age and neurodegeneration. We hypothesised that altered physiological processes are associated with recruitment and localisation of haemoglobin to these organelles. To confirm a dynamic localisation of haemoglobin we exposed Drosophila melanogaster to cyclical hypoxia with recovery. With a single cycle of hypoxia and recovery we found a relative accumulation of haemoglobin in the mitochondria compared with the cytosol. An additional cycle of hypoxia and recovery led to a significant increase of mitochondrial haemoglobin (p<0.05). We quantified ratios of human mitochondrial haemoglobin in 30 Parkinson's and matched control human post-mortem brains. Relative mitochondrial/cytosolic quantities of haemoglobin were obtained for the cortical region, substantia nigra and cerebellum. In age matched post-mortem brain mitochondrial haemoglobin ratios change, decreasing with disease duration in female cerebellum samples (n=7). The change is less discernible in male cerebellum (n=18). In cerebellar mitochondria, haemoglobin localisation in males with long disease duration shifts from the intermembrane space to the outer membrane of the organelle. These new data illustrate dynamic localisation of mitochondrial haemoglobin within the cell. Mitochondrial haemoglobin should be considered in the context of gender differences characterised in Parkinson's disease. It has been postulated that cerebellar circuitry may be activated to play a protective role in individuals with Parkinson's. The changing localisation of intracellular haemoglobin in response to hypoxia presents a novel pathway to delineate the role of the cerebellum in Parkinson's disease.

Indexed as

AgedAged, 80 and overAnimalsBrainDisease Models, AnimalDrosophila melanogasterFemaleHemoglobinsHumansHypoxiaMaleMiddle AgedMitochondriaParkinson DiseaseSex FactorsHemoglobinsCerebellumGenderHaemoglobinHypoxiaMitochondriaParkinson's disease

Identifiers

PMID27181046
PMCPMC4940210
OpenAlexW2390640775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.