SynthesisJournal of diabetes investigation2016
Serum homocysteine level and gestational diabetes mellitus: A meta-analysis.
Synthesis in Journal of diabetes investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Folic Acid Supplementation and Risk of Gestational Diabetes Mellitus: A Systematic Review of the Literature.International journal of molecular sciences · 2025Pooled it
- Serum homocysteine level and gestational diabetes mellitus: A meta-analysis.Journal of diabetes investigation · 2016Pooled it
- Observational
- Hyperhomocysteinemia reduces the high-quality embryo rate in PCOS patients undergoing IVF/ICSI: clinical evidence and a preliminary exploration of mechanisms in KGN cells.Journal of ovarian research · 2026Article
- The Role of Maternal Homocysteine Concentration in Pregnancy Complications: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Elevated homocysteine levels are associated with increased diabetes risk in patients with hypertension: a multicenter longitudinal study.Frontiers in cardiovascular medicine · 2026Article
- Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study.Nutrition journal · 2025Article
- From Pregnancy to Postpartum: The Cardiovascular Risks Associated with Gestational Diabetes.Current cardiology reviews · 2025Review
- Associations of serum choline, betaine and trimethylamine N-oxide with gestational diabetes mellitus among Chinese pregnant women.BMJ nutrition, prevention & health · 2025Article
- Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications.BMC public health · 2023Article
- Joint effect of maternal pre-pregnancy body mass index and folic acid supplements on gestational diabetes mellitus risk: a prospective cohort study.BMC pregnancy and childbirth · 2023Article
- Article
- Influence of Diet and Lifestyle on the Development of Gestational Diabetes Mellitus and on Perinatal Results.Nutrients · 2022Article
- Study on the correlation between homocysteine-related dietary patterns and gestational diabetes mellitus:a reduced-rank regression analysis study.BMC pregnancy and childbirth · 2022Article
- Association between folic acid use during pregnancy and gestational diabetes mellitus: Two population-based Nordic cohort studies.PloS one · 2022Article
- The correlation between transcription factor 7-like 2 gene polymorphisms and susceptibility of gestational diabetes mellitus in the population of central China: A case-control study.Frontiers in endocrinology · 2022Article
- The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomization study.Acta diabetologica · 2021Article
- A Novel Review of Homocysteine and Pregnancy Complications.BioMed research international · 2021Review
- Impact of the one-carbon metabolism on oocyte maturation, fertilization, embryo quality, and subsequent pregnancy.Reproductive medicine and biology · 2021Article
- The correlation between plasma total homocysteine level and gestational diabetes mellitus in a Chinese Han population.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionHomocysteine levels during pregnancy in women with gestational diabetes mellitus (GDM) have been studied; however, it remains unclear whether hyperhomocysteinemia is a useful predictor of insulin resistance. The present study aimed to evaluate the relationship between homocysteine level and GDM. MATERIALS AND
methodsPubMed, Elsevier, Web of Science and CNKI were searched for relevant studies published up to January 2015. Manual searches of references of the relevant original studies were carried out. Meta-analysis was used to assessed the relationship between homocysteine level and GDM using the stata 12.0 software.
resultsHomocysteine levels were significantly elevated in women with GDM compared with those without GDM (weighted mean difference 0.77, 95% confidence interval 0.44-1.10). This evidence was more consistent during the second trimester measurement of homocysteine (weighted mean difference 0.95, 95% confidence interval 0.67-1.23) and for women aged older than 30 years (weighted mean difference 0.90, 95% confidence interval 0.63-1.17).
conclusionsThe present meta-analysis shows that homocysteine level is significantly elevated among women with GDM compared with women with normal glucose tolerance, and this finding persists more during the second trimester.
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