Evidence map›Paper›PMID 27180150›Full record

ReviewItalian journal of pediatrics2016

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.

Victor Desmond Mandel, Flavia Persechino, Alberto Berardi, Giovanni Ponti, Silvana Ciardo, Cecilia Rossi, Giovanni Pellacani, Francesca Farnetani

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Primary Intracranial High Grade Congenital Glial Lesions (PIHGCL): A systematic review of case reports from 1985 to 2025.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Victor Desmond MandelDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
Flavia PersechinoDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
Alberto BerardiUnità Operativa di Terapia Intensiva Neonatale, Dipartimento Integrato Materno-Infantile, Azienda Ospedaliero-Universitaria Policlinico, via del Pozzo 71, Modena, 41124, Italy.
Giovanni PontiDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Clinical Pathology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
Silvana CiardoDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
Cecilia RossiTerapia Intensiva Neonatale, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico-IRCCS, viale Risorgimento 80, Reggio Emilia, 42123, Italy. cecilia.rossi@asmn.re.it.
Giovanni PellacaniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
Francesca FarnetaniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest transplant, Oncological and Regenerative Medicine, Dermatology Unit, University of Modena and Reggio Emilia, via del Pozzo 71, Modena, 41124, Italy.
University of Modena and Reggio Emilia · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico di Modena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature. CASE PRESENTATION: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions.

conclusionWe recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsApgar ScoreBrain NeoplasmsChemotherapy, AdjuvantCombined Modality TherapyDermoscopyFollow-Up StudiesGestational AgeGlioblastomaHumansInfant, NewbornMaleNeurosurgical ProceduresNevus, Epithelioid and Spindle CellRare DiseasesRisk AssessmentChemotherapyCongenital glioblastoma multiformeEruptive disseminated Spitz neviReflectance confocal microscopySpitz nevi

Identifiers

PMID27180150
PMCPMC4868014
OpenAlexW2369988405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.