SynthesisAmerican heart journal2016
Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies.
Synthesis in American heart journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program.PloS one · 2022Pooled it
- Ideal Cardiovascular Health and Risk of Cardiovascular Events or Mortality: A Systematic Review and Meta-Analysis of Prospective Studies.Journal of clinical medicine · 2023Review
- FromJournal of the American Heart Association · 2022Article
- Review
- Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment.Frontiers in pediatrics · 2022Article
- Temporal Trends and Familial Clustering of Ideal Cardiovascular Health in Parents and Offspring Over the Life Course: An Investigation Using The Framingham Heart Study.Journal of the American Heart Association · 2020Article
- Cardiometabolic Risk-Related Blood Pressure Trajectories Differ by Sex.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Promoting Cardiovascular Health in Early Childhood and Transitions in Childhood through Adolescence: A Workshop Report.The Journal of pediatrics · 2019Article
- Association between gallstone and cardio-cerebrovascular disease: Systematic review and meta-analysis.Experimental and therapeutic medicine · 2019Article
- Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2019Article
- Article
- Altered High Density Lipoprotein Composition in Behavioral Variant Frontotemporal Dementia.Frontiers in neuroscience · 2018Article
- The American Heart Association Ideal Cardiovascular Health and Incident Type 2 Diabetes Mellitus Among Blacks: The Jackson Heart Study.Journal of the American Heart Association · 2017Article
- Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine.JACC. Basic to translational science · 2017Review
Corrections and comments
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Authors and funding
21 authors at 12 institutions in 2 countries.
Funding
Abstract
backgroundMultiple genetic loci are associated with clinical cardiovascular (CV) disease and individual CV risk factors. Individuals with ideal levels of all major CV risk factors have very low risk for CV disease morbidity or mortality. Ideal levels of risk factors can be attained by lifestyle modifications; however, little is known about gene variants associated with ideal CV health. Our objective was to carry out a genome-wide association study on the trait. METHODS AND
resultsWe examined 2 dichotomous phenotypes of ideal CV health-clinical (untreated cholesterol <200 mg/dL, untreated blood pressure <120/<80, not diabetic) and clinical+behavioral (clinical plus: not a current smoker, body mass index <25 kg/m(2))-among white participants aged 50±5 years. We performed a meta-analysis of 4 genome-wide association studies (total n=11,708) from the MESA, CARDIA, ARIC, and Framingham Heart Study cohorts. We identified a single-nucleotide polymorphism (rs445925) in the APOC1/APOE region that was associated with clinical ideal CV health at genome-wide level of significance (P<2.0 × 10(-9)). The significance of this region was validated using exome chip genotyping. The association with ideal CV health was attenuated after adjusting for low-density lipoprotein cholesterol.
conclusionA common single-nucleotide polymorphism in the APOC1/APOE region, previously found to be associated with protective levels of cholesterol and lower CV risk, may be associated with ideal health. In future replication studies, larger sample sizes may be needed to detect loci with more modest effects on ideal CV health. In addition to the important impact of lifestyle modifications, we have identified evidence for gene variation that plays a role in ideal CV health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.