ArticleToxicology in vitro : an international journal published in association with BIBRA2016
Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora.
Article in Toxicology in vitro : an international journal published in association with BIBRA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- Exposure assessment of pesticide residues, heavy metals, and veterinary drugs through consumption of Egyptian fish samples.Toxicology reports · 2024Article
- The interplay of transition metals in ferroptosis and pyroptosis.Cell division · 2024Review
- Topotecan Reduces Neuron Death after Spinal Cord Injury by Suppressing Caspase-1-Dependent Pyroptosis.Molecular neurobiology · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species.Frontiers in nutrition · 2022Review
- Hypoxia-Induced ROS Contribute to Myoblast Pyroptosis during Obstructive Sleep Apnea via the NF-Oxidative medicine and cellular longevity · 2019Article
- Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice.Neurotoxicology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Zinc is both an essential and potentially toxic metal. It is widely believed that oral zinc supplementation can reduce the effects of the common cold; however, there is strong clinical evidence that intranasal (IN) zinc gluconate (ZG) gel treatment for this purpose causes anosmia, or the loss of the sense of smell, in humans. Using the rat olfactory neuron cell line, Odora, we investigated the molecular mechanism by which zinc exposure exerts its toxic effects on olfactory neurons. Following treatment of Odora cells with 100 and 200μM ZG for 0-24h, RNA-seq and in silico analyses revealed up-regulation of pathways associated with zinc metal response, oxidative stress, and ATP production. We observed that Odora cells recovered from zinc-induced oxidative stress, but ATP depletion persisted with longer exposure to ZG. ZG exposure increased levels of NLRP3 and IL-1β protein levels in a time-dependent manner, suggesting that zinc exposure may cause an inflammasome-mediated cell death, pyroptosis, in olfactory neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.