ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016
Management of infectious intracranial aneurysms in the pediatric population.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Ruptured distal middle cerebral artery aneurysm in a pediatric patient: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Microsurgical management of a ruptured intracranial mycotic aneurysm in infancy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Newly formed and ruptured infectious intracranial aneurysm in few days following first intracranial aneurysm embolization concurrent with middle cerebral artery occlusion: A regrettable case in a baby child.Pediatric discovery · 2024Article
- Risk factors of intracranial infection in patients after intracranial aneurysm surgery: Implication for treatment strategies.Medicine · 2021Article
- Successful endovascular treatment of pediatric basilar infectious (mycotic) aneurysm: a case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Successful flow diversion treatment of ruptured infectious middle cerebral artery aneurysms with the use of Pipeline Flex with Shield technology.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021Article
- Article
- Malignant clinical course of mycotic intracranial aneurysms in children: A review.Surgical neurology international · 2020Article
- Intracranial vessel occlusion preceding the development of mycotic aneurysms in patients with endocarditis.BMJ case reports · 2019Article
- Onyx embolization of a ruptured anterior inferior cerebellar artery in a neonate.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Imaging of cerebrovascular complications of infection.Quantitative imaging in medicine and surgery · 2018Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfectious intracranial aneurysms (IIAs) account for approximately 15 % of all pediatric intracranial aneurysms. Histologically, they are pseudoaneurysms that develop in response to an inflammatory reaction within the adventitia and muscularis layers, ultimately resulting in disruption of both the internal elastic membrane and the intima. The majority of pediatric IIAs are located within the anterior circulation, and they can be multiple in 15-25 % of cases.
backgroundThe most common presentation for an IIA is intracerebral and/or subarachnoid hemorrhage. In children with a known diagnosis of infective endocarditis who develop new neurological manifestations, it is imperative to exclude the existence of an IIA. The natural history of untreated infectious aneurysms is ominous; they demonstrate a high incidence of spontaneous rupture. High clinical suspicion, prompt diagnosis, and adequate treatment are of paramount importance to prevent devastating neurological consequences. DISCUSSION: The prompt initiation of intravenous broad-spectrum antibiotics represents the mainstay of treatment. Three questions should guide the management of pediatric patients with IIAs: (a) aneurysm rupture status, (b) the presence of intraparenchymal hemorrhage or elevated intracranial pressure, and (c) relationship of the parent vessel to eloquent brain tissue. Those three questions should orient the treating physician into either antibiotic therapy alone or in combination with microsurgical or endovascular interventions. This review discusses important aspects of the epidemiology, the diagnosis, and the management of IIAs in the pediatric population.
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