ArticlePsychiatry research. Neuroimaging2016
Greater hippocampal volume is associated with PTSD treatment response.
Article in Psychiatry research. Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness and moderators of PE and CPT in adult PTSD treatment: a systematic review and meta-analysis.European journal of psychotraumatology · 2026Pooled it
- Neurobiological Alterations in Females With PTSD: A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- Does trauma-focused psychotherapy change the brain? A systematic review of neural correlates of therapeutic gains in PTSD.European journal of psychotraumatology · 2021Pooled it
- Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.Biological psychiatry · 2018Pooled it
- Anterior hippocampal volume predicts affect-focused psychotherapy outcome.Psychological medicine · 2020Trial
- History of sexual trauma moderates psychotherapy outcome for posttraumatic stress disorder.Depression and anxiety · 2017Trial
- Hyperpolarization-Activated Channel 1 Modulates Resilience and Susceptibility to Social Avoidance Induced by Witnessing Social Defeat Stress.Biological psychiatry · 2025Article
- The association between childhood adversity and hippocampal volumes is moderated by romantic relationship experiences.The European journal of neuroscience · 2025Article
- Interactions of the CSF3R polymorphism and early stress on future orientation: evidence for the differential model of stress-related growth.Epidemiology and psychiatric sciences · 2024Article
- Trauma and the default mode network: review and exploratory study.Frontiers in behavioral neuroscience · 2024Article
- Acceptance and Mindfulness-Based Exposure Therapy for PTSD After Cardiac Arrest: An Open Feasibility Trial.The Journal of clinical psychiatry · 2023Article
- Underlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials.Biological psychiatry global open science · 2023Article
- Chronic fluoxetine enhances extinction therapy for PTSD by evaluating brain glucose metabolism in rats: an [Annals of nuclear medicine · 2022Article
- Evaluation of brain structure and metabolism in currently depressed adults with a history of childhood trauma.Translational psychiatry · 2022Article
- The relationship between recent PTSD secondary to sexual assault, hippocampal volume and resting state functional connectivity in adolescent girls.Neurobiology of stress · 2022Article
- Acute Posttraumatic Symptoms Are Associated With Multimodal Neuroimaging Structural Covariance Patterns: A Possible Role for the Neural Substrates of Visual Processing in Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Spontaneous brain activity, graph metrics, and head motion related to prospective post-traumatic stress disorder trauma-focused therapy response.Frontiers in human neuroscience · 2022Article
- Repeated cocaine exposure prior to fear conditioning induces persistency of PTSD-like symptoms and enhancement of hippocampal and amygdala cell density in male rats.Brain structure & function · 2021Article
- PTSD: Past, present and future implications for China.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2021Review
- The environment contributes more than genetics to smaller hippocampal volume in Posttraumatic Stress Disorder (PTSD).Journal of psychiatric research · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Previous research associates smaller hippocampal volume with posttraumatic stress disorder (PTSD). It is unclear, however, whether treatment affects hippocampal volume or vice versa. Seventy-six subjects, 40 PTSD patients and 36 matched trauma-exposed healthy resilient controls, underwent clinical assessments and magnetic resonance imaging (MRI) at baseline, and 10 weeks later, during which PTSD patients completed ten weeks of Prolonged Exposure (PE) treatment. The resilient controls and treatment responders (n=23) had greater baseline hippocampal volume than treatment non-responders (n=17) (p=0.012 and p=0.050, respectively), perhaps due to more robust fear-extinction capacity in both the initial phase after exposure to trauma and during treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.