Evidence map›Paper›PMID 27179074›Full record

ArticleJournal of cell science2016

Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.

Leena Baker, Michael BeGora, Faith Au Yeung, Michael E Feigin, Avi Z Rosenberg, Scott W Lowe, Thomas Kislinger, Senthil K Muthuswamy

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Role of RhoC in cancer cell migration.Cancer cell international · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Leena BakerDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada.
Michael BeGoraPrincess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Faith Au YeungPrincess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Michael E FeiginCold Spring Harbor Laboratory, Watson School of Biological Sciences, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Avi Z RosenbergCold Spring Harbor Laboratory, Watson School of Biological Sciences, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Scott W LoweHoward Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Thomas KislingerDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, M5G 2M9, Canada.
Senthil K MuthuswamyDepartment of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, M5G 2M9, Canada Department of Medicine, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA 02215, USA smuthusw@bidmc.harvard.edu.ORCID 0000-0001-6564-9634
University Health Network · CACold Spring Harbor Laboratory · USBeth Israel Deaconess Medical Center · USMemorial Sloan Kettering Cancer Center · USUniversity of Toronto · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8M
Early events of carcinoma induced by ErbB receptorsR01CA098830 · NCI · COLD SPRING HARBOR LABORATORY · PI MUTHUSWAMY, SENTHIL K · 2003 to 2013
$3.4M
A scalable platform for target validation in GEMM models of gastrointestinal malignancies.R01CA195787 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W. · 2015 to 2017
$2.0M
NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA098830NCI NIH HHS R01 CA195787
6 · The paper itself

Abstract

The cell polarity protein scribble (SCRIB) is a crucial regulator of polarization, cell migration and tumorigenesis. Whereas SCRIB is known to regulate early stages of mouse mammary gland development, its function in the adult gland is not known. Using an inducible RNA interference (RNAi) mouse model for downregulating SCRIB expression, we report an unexpected role for SCRIB as a positive regulator of cell proliferation during pregnancy-associated mammary alveologenesis. SCRIB was required in the epithelial cell compartment of the mammary gland. Lack of SCRIB attenuated prolactin-induced activation of the JAK2-STAT5 signaling pathway. In addition, loss of SCRIB resulted in the downregulation of prolactin receptor (PRLR) at cell surface and its accumulation in intracellular structures that express markers of the Golgi complex and the recycling endosome. Unlike its role in virgin gland as a negative regulator cell proliferation, SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy.

Indexed as

OrganogenesisAgingAnimalsEpithelial CellsFemaleGene Knockdown TechniquesIntracellular Signaling Peptides and ProteinsJanus Kinase 2Mammary Glands, AnimalMicePregnancyProlactinReceptors, ProlactinSignal TransductionSTAT5 Transcription FactorIntracellular Signaling Peptides and ProteinsJak2 protein, mouseJanus Kinase 2ProlactinReceptors, Prolactinscrib protein, mouseSTAT5 Transcription FactorMammary alveologenesisProliferationScribble

Identifiers

PMID27179074
PMCPMC4920253
OpenAlexW2370311828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.