Observational studyClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016
GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness.
Observational study in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Anesthesia-induced electroencephalogram oscillations and perioperative outcomes in older adults undergoing cardiac surgery.Journal of clinical anesthesia · 2025Trial
- Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans.Anesthesiology · 2020Trial
- Dissociative and Analgesic Properties of Ketamine Are Independent.Anesthesiology · 2020Trial
- Trial
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Enhanced Sensitivity and Altered EEG Patterns During General Anesthesia in BTBR Mice, a Model of Autism.Brain sciences · 2026Article
- Divergent periodic and aperiodic EEG signatures of Propofol versus sevoflurane anesthesia: a comparative neurophysiological study.Frontiers in medicine · 2026Article
- Electroencephalogram signatures of propanidid-mediated sedation and unconsciousness.Journal of neurophysiology · 2025Article
- Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane.Fundamental research · 2025Article
- Article
- Propofol modulates neural dynamics of thalamo-cortical system associated with anesthetic levels in rats.Cognitive neurodynamics · 2023Article
- Modulatory dynamics mark the transition between anesthetic states of unconsciousness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Intraoperative electroencephalographic marker of preoperative frailty: A prospective cohort study.Journal of clinical anesthesia · 2023Article
- Facilitation of Behavioral and Cortical Emergence from Isoflurane Anesthesia by GABAergic Neurons in Basal Forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Effects of General Anesthetics on Synaptic Transmission and Plasticity.Current neuropharmacology · 2022Review
- Biophysical Model: A Promising Method in the Study of the Mechanism of Propofol: A Narrative Review.Computational intelligence and neuroscience · 2022Review
- Ketamine induces EEG oscillations that may aid anesthetic state but not dissociation monitoring.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Association Between Burst-Suppression Latency and Burst-Suppression Ratio Under Isoflurane or Adjuvant Drugs With Isoflurane Anesthesia in Mice.Frontiers in pharmacology · 2021Article
- A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine.Anesthesiology · 2020Article
- Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models.Journal of neural engineering · 2020Article
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6 authors.
Funding
Abstract
objectiveAn emerging paradigm for understanding how anesthetics induce altered arousal is relating receptor targeting in specific neural circuits to electroencephalogram (EEG) activity. Enhanced gamma amino-butyric acid A (GABAA) inhibitory post-synaptic currents (IPSCs) manifest with large-amplitude slow (0.1-1Hz) and frontally coherent alpha (8-12Hz) EEG oscillations during general anesthesia. Therefore, we investigated the EEG signatures of modern day derivatives of ether (MDDE) anesthesia to assess the extent to which we could obtain insights into MDDE anesthetic mechanisms.
methodsWe retrospectively studied cases from our database in which patients received isoflurane anesthesia vs. isoflurane/ketamine anesthesia (n=10 each) or desflurane anesthesia vs. desflurane/ketamine anesthesia (n=9 each). We analyzed the EEG recordings with spectral power and coherence methods.
resultsSimilar to known GABAA circuit level mechanisms, we found that MDDE anesthesia induced large amplitude slow and frontally coherent alpha oscillations. Additionally, MDDE anesthesia also induced frontally coherent theta (4-8Hz) oscillations. Reduction of GABAergic IPSCs with ketamine resulted in beta/gamma (13-40Hz) oscillations, and significantly reduced MDDE anesthesia-induced slow, theta and alpha oscillation power.
conclusionsLarge amplitude slow oscillations and coherent alpha and theta oscillations are moderated by ketamine during MDDE anesthesia. SIGNIFICANCE: These observations are consistent with the notion that GABAA circuit-level mechanisms are associated with MDDE anesthesia-induced unconsciousness.
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