Evidence map›Paper›PMID 27178863›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016

Early event-related potentials to emotional faces differ for adults with autism spectrum disorder and by serotonin transporter genotype.

Susan Faja, Geraldine Dawson, Elizabeth Aylward, Ellen M Wijsman, Sara Jane Webb

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
    Pooled it
  4. Article
  5. Article
  6. Infants' neural responses to emotional faces are related to maternal anxiety.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susan FajaUniversity of Washington, Department of Psychology, Box 351525, Seattle, WA 98195, USA.
Geraldine DawsonUniversity of Washington, Department of Psychology, Box 351525, Seattle, WA 98195, USA; University of Washington, Department of Psychiatry and Behavioral Sciences, Box 356560, Room BB1644, Seattle, WA 98195, USA.
Elizabeth AylwardCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101, USA.
Ellen M WijsmanUniversity of Washington, Department of Medicine, Division of Medical Genetics, Box 356420, Seattle, WA 98195, USA; University of Washington, Department of Biostatistics, Box 357232, Seattle, WA 98195, USA.
Sara Jane WebbUniversity of Washington, Department of Psychiatry and Behavioral Sciences, Box 356560, Room BB1644, Seattle, WA 98195, USA. Electronic address: sjwebb@uw.edu.

Funding

UW Autism Center of ExcellenceP50HD055782 · NICHD · UNIVERSITY OF WASHINGTON · PI WIJSMAN, ELLEN M · 2007 to 2011
$11.0M
UW Autism Research Center of ExcellenceU54MH066399 · NIMH · UNIVERSITY OF WASHINGTON · PI DAGER, STEPHEN R · 2003 to 2007
$8.3M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
2/3 Sequencing Autism Spectrum Disorder Extended PedigreesR01MH094293 · NIMH · UNIVERSITY OF WASHINGTON · PI WIJSMAN, ELLEN M · 2012 to 2016
$1.1M
NICHD NIH HHS P50 HD055782NICHD NIH HHS U54 HD083091NIMH NIH HHS R01 MH094293NIMH NIH HHS U54 MH066399
6 · The paper itself

Abstract

objectiveTo test differences in neural sensitivity to facial expressions, including expressions with open versus closed mouths, exhibited by (1) adults with autism spectrum disorder (ASD) compared to neurotypical adults, and by (2) short versus long serotonin transporter allele (SLC6A4) carriers.

methodsEvent related potentials (ERPs) to happy, fearful, and neutral expressions were collected from neurotypical adults (n=25) and adults with ASD (n=27)-of whom 32 had short and 13 had homozygous long SLC6A4 alleles.

resultsIn the neurotypical group, we confirmed that the N170, VPP and EPN, but not the P1, were influenced by emotional expressions, and determined the EPN was the earliest component modulated by open mouth. Compared to the neurotypical group, individuals with ASD exhibited differences in EPN amplitude in response to open versus closed mouths and in hemispheric distribution. Across groups, short serotonin transporter allele carriers had reduced P1 amplitude compared to long allele carriers.

conclusionsIndividuals with ASD exhibited a different pattern of neural response when encoding and recognizing facial expressions at the EPN component. Across groups, SLC6A4 allele type modulated early sensory attention at the P1. SIGNIFICANCE: These results provide insight into the nature of early responses to emotional information according to genetic variation and clinical condition.

Indexed as

Evoked PotentialsFacial ExpressionGenotypeAdolescentAdultAutism Spectrum DisorderCase-Control StudiesEmotionsFemaleHumansMalePolymorphism, Single NucleotideSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanAutismElectrophysiologyEmotionEvent related potentialSerotoninSLC6A4

Identifiers

PMID27178863
PMCPMC5279301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.