ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016
Freezing of gait is associated with increased saccade latency and variability in Parkinson's disease.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Antisaccades in Parkinson's Disease: A Meta-Analysis.Neuropsychology review · 2021Pooled it
- Trial
- The role of the prefrontal cortex in freezing of gait in Parkinson's disease: insights from a deep repetitive transcranial magnetic stimulation exploratory study.Experimental brain research · 2017Trial
- Auto detection and segmentation of daily living activities during a Timed Up and Go task in people with Parkinson's disease using multiple inertial sensors.Journal of neuroengineering and rehabilitation · 2017Trial
- The spectrum of square wave jerks in essential tremor: an exploratory study.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Clinical Validation of Pupil Response During Walking in Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Integrating Eye Tracking and Inertial Sensing for Enhanced Freezing of Gait Detection in Parkinson's Disease.The European journal of neuroscience · 2026Article
- Instability of Oculomotor Control in Parkinson's Disease Without Freezing of Gait: Evidence From Reflexive and Voluntary Saccade Variability.The European journal of neuroscience · 2026Article
- Towards scalable screening for the early detection of Parkinson's disease: validation of an iPad-based eye movement assessment system against a clinical-grade eye tracker.NPJ Parkinson's disease · 2025Article
- REM density in Parkinson's disease: association with motor, cognitive, autonomic function, and dopaminergic medication.NPJ Parkinson's disease · 2025Article
- The relation of eye movements to the occurrence of freezing of gait in Parkinson's disease.Brain communications · 2025Article
- Effects of a treadmill and oculomotor dual-task intervention vs. -nordic walking on balance in Parkinson's disease patients - a pilot study.Clinical parkinsonism & related disorders · 2025Article
- Observational
- Topography of Cholinergic Nerve Terminal Vulnerability and Balance Self-Efficacy in Parkinson's Disease.Journal of integrative neuroscience · 2024Observational
- Oculometric measures as a tool for assessment of clinical symptoms and severity of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- Gaze-Contingent Eye-Tracking Training in Brain Disorders: A Systematic Review.Brain sciences · 2022Review
- Freezing of saccades in dopa-responsive parkinsonian syndrome.American journal of ophthalmology case reports · 2021Article
- Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review.Frontiers in neurology · 2020Review
- Clinical and Oculomotor Correlates With Freezing of Gait in a Chinese Cohort of Parkinson's Disease Patients.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveFreezing of gait (FOG) is a locomotor disturbance in Parkinson disease (PD) related to impaired motor automaticity. In this study, we investigated the impact of freezing on automaticity in the oculomotor system using an anti-saccade paradigm.
methodsSubjects with PD with (PD-FOG, n=13) and without (PD-NON, n=13) FOG, and healthy age-matched controls (CTRL, n=12) completed automatic pro-saccades and non-automatic anti-saccades. Primary outcomes were saccade latency, velocity, and gain.
resultsPD-FOG (pro-saccade latency=271ms, anti-saccade latency=412ms) were slower to execute both types of saccades compared to PD-NON (253ms, 330ms) and CTRL (246ms, 327ms). Saccade velocity and gain variability was also increased in PD-FOG.
conclusionsSaccade performance was affected in PD-FOG for both types of saccades, indicating differences in automaticity and control in the oculomotor system related to freezing. SIGNIFICANCE: These results and others show that FOG impacts non-gait motor functions, suggesting global motor impairment in PD-FOG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.