ArticleCerebral cortex (New York, N.Y. : 1991)2017
Reorganization of Functional Networks in Verbal Working Memory Circuitry in Early Midlife: The Impact of Sex and Menopausal Status.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed.
- The Mind From Within: Visceral Roots of Human Cognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Estradiol and memory circuitry in the postmenopause: Modification by APOE4.Research square · 2026Article
- Distinct intrinsic neural connectivity of an emotion regulation network across the menopausal transition.Comprehensive psychoneuroendocrinology · 2026Article
- Dense longitudinal neuroimaging reveals individual brain change trajectories.Trends in cognitive sciences · 2026Review
- Neurobiological Signatures of Endometriosis: Characterizing Pain, Cognition, and Brain Morphology.bioRxiv : the preprint server for biology · 2026Article
- Trajectories and timing of accelerated decline in specific memory domains preceding Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Loss of ovarian hormones is detrimental in early disease stages of mouse models of Alzheimer's disease and multi-etiology dementia.Biology of sex differences · 2025Article
- Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer's risk via ERRα dysregulation and energy dyshomeostasis.Nature communications · 2025Article
- Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife.Journal of Alzheimer's disease : JAD · 2025Article
- Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation.Nutrients · 2025Review
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Endogenous Estrogens and Brain Activation During Verbal Memory Encoding and Recognition in the Postmenopause.The Journal of clinical endocrinology and metabolism · 2025Article
- Leukocyte telomere length and memory circuitry and cognition in early aging: Impact of sex and menopausal status.Hormones and behavior · 2024Article
- Diurnal Fluctuations in Steroid Hormones Tied to Variation in Intrinsic Functional Connectivity in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Impact of sex and reproductive status on the default mode network in early midlife: implications for aging of memory circuitry and function.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Sex-dependent alterations in hippocampal connectivity are linked to cerebrovascular and amyloid pathologies in normal aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Diurnal fluctuations in steroid hormones tied to variation in intrinsic functional connectivity in a densely sampled male.bioRxiv : the preprint server for biology · 2023Article
- Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and nonusers.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age-related differences in functional network segregation in the context of sex and reproductive stage.Human brain mapping · 2023Article
- Sex Differences in Cognition Across Aging.Current topics in behavioral neurosciences · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Converging preclinical and human evidence indicates that the decline in ovarian estradiol production during the menopausal transition may play a mechanistic role in the neuronal changes that occur early in the aging process. Here, we present findings from a population-based fMRI study characterizing regional and network-level differences in working memory (WM) circuitry in midlife men and women (N = 142; age range 46-53), as a function of sex and reproductive stage. Reproductive histories and hormonal evaluations were used to determine menopausal status. Participants performed a verbal WM task during fMRI scanning. Results revealed robust differences in task-evoked responses in dorsolateral prefrontal cortex and hippocampus as a function of women's reproductive stage, despite minimal variance in chronological age. Sex differences in regional activity and functional connectivity that were pronounced between men and premenopausal women were diminished for postmenopausal women. Critically, analyzing data without regard to sex or reproductive status obscured group differences in the circuit-level neural strategies associated with successful working memory performance. These findings underscore the importance of reproductive age and hormonal status, over and above chronological age, for understanding sex differences in the aging of memory circuitry. Further, these findings suggest that early changes in working memory circuitry are evident decades before the age range typically targeted in cognitive aging studies.
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