ArticleJournal of neurology2016
Tissue damage within normal appearing white matter in early multiple sclerosis: assessment by the ratio of T1- and T2-weighted MR image intensity.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- T1-weighted/T2-weighted ratio reflects microstructural changes in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Phase Locking of 40 Hz Auditory Steady State Responses Is Modulated by Sensory Predictability and Linked to Cerebellar Myelination.Human brain mapping · 2025Article
- The temporal dynamics and clinical relevance of choroid plexus measures in multiple sclerosis.Brain communications · 2025Article
- Approximating R1 and R2: A Quantitative Approach to Clinical Weighted MRI.Human brain mapping · 2024Article
- Radiomics score derived from T1-w/T2-w ratio image can predict motor symptom progression in Parkinson's disease.European radiology · 2024Article
- Association between T1w/T2w ratio in white matter and cognitive function in Alzheimer's disease.Scientific reports · 2024Article
- Abnormal Magnetic Resonance Image Signature in Virologically Stable HIV Individuals.The Journal of infectious diseases · 2022Article
- T1/T2-weighted ratio is a surrogate marker of demyelination in multiple sclerosis: No.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- T1w/FLAIR ratio standardization as a myelin marker in MS patients.NeuroImage. Clinical · 2022Article
- Longitudinal analysis of T1w/T2w ratio in patients with multiple sclerosis from first clinical presentation.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Magnetic resonance T1w/T2w ratio and voxel-based morphometry in multiple system atrophy.Scientific reports · 2021Article
- Revisiting the global workspace orchestrating the hierarchical organization of the human brain.Nature human behaviour · 2021Article
- N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation.The Journal of biological chemistry · 2020Article
- Article
- Ratio of T1-Weighted to T2-Weighted Signal Intensity as a Measure of Tissue Integrity: Comparison with Magnetization Transfer Ratio in Patients with Multiple Sclerosis.AJNR. American journal of neuroradiology · 2020Article
- Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.NeuroImage. Clinical · 2020Article
- Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans.NeuroImage. Clinical · 2020Article
- Influence of 7T GRE-MRI Signal Compartment Model Choice on Tissue Parameters.Frontiers in neuroscience · 2020Article
- Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histopathological and magnetic resonance imaging (MRI) studies have shown white matter (WM) damage in early stages of multiple sclerosis (MS) beyond the apparent T2-hyperintense lesions. These changes in normal appearing WM (NAWM) are important with regard to the clinical picture and prognosis. However, the detection of changes within NAWM has so far required special imaging techniques commonly not available in clinical routine and, hence, at large scale. The purpose of this study was to detect MS-related damage of NAWM by conventional MRI. As, within NAWM, the myelin content mainly drives the T1-weighted (T1w) signal, we scaled it by the T2w signal. We tested the hypothesis that the mean T1w/T2w ratio of NAWM is decreased in MS compared to healthy controls (HC) and that it correlates with clinical measures. We developed a pipeline to determine the individual mean values of this ratio within NAWM. We studied 244 patients in early disease stages of MS (mean age 37 ± 10 years, mean disease duration 3.1 ± 2.3, Expanded Disability Status Scale 1.3 ± 1), and 78 HC (mean age 31 ± 8 years). Compared to HC, the mean T1w/T2w ratio was lowered in the patient group (P < 0.001). The difference remained significant after restricting the analysis to patients with a disease duration of 5 years or less and without disease modifying drugs. Our measures also correlated with clinical scores. We believe that the mean T1w/T2w ratio is a promising candidate to assess MS-related tissue damage within NAWM at large scale.
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