Evidence map›Paper›PMID 27177929›Full record

Observational studyAcupuncture in medicine : journal of the British Medical Acupuncture Society2016

Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve: a prospective observational study.

Yang Wang, Yanhong Li, Ruixue Chen, Xiaoming Cui, Jinna Yu, Zhishun Liu

2 registry-linked trialsOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02229604 phase1completednot on this map

Electroacupuncture for Diminished Ovarian Reserve-a Cohort Study

TypeinterventionalSponsorGuang'anmen Hospital of China Academy of Chinese Medical SciencesRan2014 to 2016Enrolled57ConditionsIrregular MensesArmsEA, HRT, DHEA and herb
NCT05743218 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Clinical Study of Liver Meridian in the Treatment of Male Impotence and Female Premature Ovarian Failure

TypeinterventionalSponsorThe First Affiliated Hospital of Hunan University of Traditional Chinese MedicineRan2023 to 2023Enrolled198ConditionsOvarian Reserve, Acupuncture Therapy, MeridianArmselectropuncture
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yang WangAcupuncture Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Yanhong LiGynecology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Ruixue ChenGynecology Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaoming CuiAcupuncture Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Jinna YuAcupuncture Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Zhishun LiuAcupuncture Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNGuang’anmen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEffective methods for the treatment of reproductive dysfunction are limited. Previous studies have reported that acupuncture can modulate female hormone levels, improve menstrual disorders, alleviate depression and improve pregnancy rates. However, studies of acupuncture for diminished ovarian reserve (DOR) are lacking.

objectiveTo carry out a prospective observational study aimed at assessing the effect of EA on the reproductive hormone levels of patients with DOR seeking fertility support and consider its safety.

methodsEligible patients with DOR received EA for 12 weeks: five times a week for 4 weeks followed by three times a week for 8 weeks. The primary outcome was the change in mean follicle-stimulating hormone (FSH) level at week 12. Mean luteinising hormone (LH) and serum oestradiol (E2) levels, FSH/LH ratios and symptom scale scores were simultaneously observed.

resultsTwenty-one patients with DOR were included in the final analysis. Mean FSH levels fell from 19.33±9.47 mIU/mL at baseline to 10.58±6.34 mIU/mL at week 12 and 11.25±6.68 mIU/mL at week 24. Change in mean FSH from baseline was -8.75±11.13 mIU/mL at week 12 (p=0.002) and -8.08±9.56 mIU/mL at week 24 (p=0.001). Mean E2 and LH levels, FSH/LH ratios and irritability scores were improved at weeks 12 and/or 24. Approximately 30% patients reported subjective increases in menstrual volume after treatment.

conclusionsEA may modulate reproductive hormone levels and the effects seem to persist for at least 12 weeks after treatment with no significant side effects. EA may improve the ovarian reserve of patients with DOR, though further research is needed. TRIAL REGISTRATION NUMBER: NCT02229604; Results.

Indexed as

Ovarian ReserveAdultElectroacupunctureEstradiolFemaleFollicle Stimulating HormoneHumansInfertility, FemaleLuteinizing HormoneMenstruationOvarian DiseasesPregnancyProspective StudiesTime FactorsTreatment OutcomeEstradiolFollicle Stimulating HormoneLuteinizing HormoneCOMPLEMENTARY MEDICINEGYNAECOLOGY

Identifiers

PMID27177929
PMCPMC5099178
OpenAlexW2391269107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.