Evidence map›Paper›PMID 27177902›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

TUSC3 suppresses glioblastoma development by inhibiting Akt signaling.

Zhenfeng Jiang, Mian Guo, Xiangtong Zhang, Lifen Yao, Jia Shen, Guizhen Ma, Li Liu, Liwei Zhao, Chuncheng Xie, Hongsheng Liang and 6 more

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  10. TUSC3: functional duality of a cancer gene.Cellular and molecular life sciences : CMLS · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Zhenfeng JiangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Mian GuoDepartment of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiangtong ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Lifen YaoDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Jia ShenOrthopaedic Hospital Research Center, University of California, Los Angeles, CA, USA.
Guizhen MaDepartment of Operating Rooms, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Li LiuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Liwei ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Chuncheng XieDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Hongsheng LiangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Haiyang WangDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Minwei ZhuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Li HuDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Yuanyuan SongDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Hong ShenDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China.
Zhiguo LinDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Harbin, Heilongjiang Province, 150001, China. linzhiguo2009@sohu.com.
Harbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNOrthopaedic Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiform is one of the most common and most aggressive brain tumors in humans. The molecular and cellular mechanisms responsible for the onset and progression of GBM are elusive and controversial. The function of tumor suppressor candidate 3 (TUSC3) has not been previously characterized in GBM. TUSC3 was originally identified as part of an enzyme complex involved in N-glycosylation of proteins, but was recently implicated as a potential tumor suppressor gene in a variety of cancer types. In this study, we demonstrated that the expression levels of TUSC3 were downregulated in both GBM tissues and cells, and also found that overexpression of TUSC3 inhibits GBM cell proliferation and invasion. In addition, the effects of increased levels of methylation on the TUSC3 promoter were responsible for decreased expression of TUSC3 in GBM. Finally, we determined that TUSC3 regulates proliferation and invasion of GBM cells by inhibiting the activity of the Akt signaling pathway.

Indexed as

Brain NeoplasmsCell Line, TumorCell ProliferationDNA MethylationGlioblastomaGlycosylationHumansMembrane ProteinsNeoplasm InvasivenessPromoter Regions, GeneticProto-Oncogene Proteins c-aktSignal TransductionTumor Suppressor ProteinsMembrane ProteinsProto-Oncogene Proteins c-aktTumor Suppressor ProteinsTUSC3 protein, humanAkt signalingGlioblastomaMethylationTUSC3

Identifiers

PMID27177902
OpenAlexW2356973932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.