ArticleThe Annals of thoracic surgery2016
Neither Maximum Tumor Size nor Solid Component Size Is Prognostic in Part-Solid Lung Cancer: Impact of Tumor Size Should Be Applied Exclusively to Solid Lung Cancer.
Article in The Annals of thoracic surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- The Epidemiology of Ground Glass Opacity Lung Adenocarcinoma: A Network-Based Cumulative Meta-Analysis.Frontiers in oncology · 2020Pooled it
- A Novel Tumor Burden Index to Predict the Prognosis in Stage IA Lung Adenocarcinoma.Annals of surgical oncology · 2026Article
- Tumor Mass Is a Better Prognostic Factor Than Consolidation-to-Tumor Ratio in Invasive Lung Adenocarcinoma Manifest Difficult-to-Measure Solid Portion.JTO clinical and research reports · 2026Article
- Machine learning models predict survival in unresectable stage III non-small cell lung cancer: Surveillance, Epidemiology, and End Results and Chinese cohort study.Journal of thoracic disease · 2026Article
- Radiological pure-solid appearance clinical stage I lung adenocarcinoma: a comparative study of mucinous and non-mucinous adenocarcinoma based on imaging features and survival outcomes.Insights into imaging · 2026Article
- Evaluation of high-grade growth patterns in invasive adenocarcinomas manifesting as ground-glass lesions via clinical and qualitative and quantitative computed tomography features.Quantitative imaging in medicine and surgery · 2026Article
- Proposal on incorporating consolidation-to-tumor ratio into the clinical T1 classification in patients with invasive lung adenocarcinoma.Translational lung cancer research · 2026Article
- Application of an improved YOLOv5s-based deep learning model for automated detection of pulmonary adenocarcinomaFrontiers in medicine · 2026Article
- Surgical Challenge of Sublobar Resection for Early-stage Non-small Cell Lung Cancer: Current Status and Future Perspectives.Juntendo medical journal · 2026Article
- Article
- Utilizing Clinicopathological and Radiomic Features for Risk Stratification of Lung Cancer Recurrence.Academic radiology · 2025Article
- Article
- Prognostic role of subsolid ground-glass opacity, pure ground-glass opacity, and solid nodules of the lung: a retrospective observational study.Journal of thoracic disease · 2025Article
- Radiofrequency Ablation Versus Thoracoscopic Sublobar Resection for the Treatment of Pulmonary Ground Glass Nodules: A Retrospective Observational Study.Cardiovascular and interventional radiology · 2025Observational
- Reassessment of the Prognostic Implication of Ground-Glass Opacity: An Investigation Into Hypermetabolic Clinical Stage IA Lung Adenocarcinoma.Thoracic cancer · 2025Article
- Article
- Precise diagnosis and prognosis assessment of malignant lung nodules: a narrative review.Journal of thoracic disease · 2024Review
- Prognostic significance using histologic subtype in stage I lung adenocarcinoma.Journal of thoracic disease · 2024Article
- Predicting prognosis in patients with stage IA lung adenocarcinoma with a micropapillary component using a nomogram based on computed tomography radiomics and clinicopathologic factors: a retrospective analysis.Translational lung cancer research · 2024Article
- Multimodal deep learning radiomics model for predicting postoperative progression in solid stage I non-small cell lung cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
9 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to investigate the prognostic impact of tumor size based on the consolidation status by thin-section computed tomography.
methodsWe evaluated 1,181 surgically resected clinical N0 M0 non-small cell lung carcinomas. Consolidation tumor ratio (CTR) was evaluated for all, and tumors were classified into three groups, namely pure ground-glass opacity (CTR = 0; n = 168), part-solid (0 < CTR < 1.0; n = 448), and solid (CTR = 1.0; n = 565). The impact of tumor size was assessed based on CTR using Cox proportional hazards model.
resultsTumor size significantly differentiated the 5-year overall survival (≤20 mm; n = 638: 93.4%; 21-30 mm; n = 284: 84.2%; 31-50 mm; n = 193: 69.3%; ≥51 mm; n = 66: 43.5%; p < 0.0001). When we evaluated the impact of tumor size based on CTR, the 5-year overall survival differed significantly in patients with radiologic solid lung cancer (≤20 mm: 83.0%; 21-30 mm: 75.4%; 31-50 mm: 56.2%; ≥51 mm: 45.3%; p < 0.0001). In contrast, it did not affect the 5-year overall survival in patients with radiologic pure ground-glass opacity (100% regardless of the tumor sizes) and part-solid lung cancer (≤20 mm: 97.7%; 21-30 mm: 94.6%; 31-50 mm: 93.4%; p = 0.1028; 0 < CTR ≤ 0.5: 98.4%; 0.5 < CTR < 1.0: 95.0%; p = 0.1247). Furthermore, maximum tumor size (p = 0.6370), solid component size (p = 0.2340), and CTR (p = 0.1395) were not associated with poor overall survival in radiologic part-solid lung cancer.
conclusionsThe impact of maximum tumor size should be applied only to radiologic solid lung cancer without the ground-glass opacity component on thin-section computed tomography. On the other hand, we recommend that pure ground-glass opacity and part-solid lung cancers be described, respectively, as clinical-Tis and clinical-T1a, which are independent of maximum tumor size and solid component size on thin-section computed tomography.
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