Evidence map›Paper›PMID 27177639›Full record

ReviewCurrent gastroenterology reports2016

Eradication of Helicobacter pylori Infection.

Elizabeth A Marcus, George Sachs, David R Scott

Abstract readReview
In one paragraph

Review in Current gastroenterology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Eradication ofFuture science OA · 2024
    Article
  7. Article
  8. World journal of clinical cases · 2022
    Article
  9. Article
  10. The Effects of Vitamins and Micronutrients onJournal of immunology research · 2022
    Review
  11. Asclepain cI, a proteolytic enzyme fromFrontiers in microbiology · 2022
    Article
  12. The influence of P-glycoprotein expression in the standard treatment of Helicobacter pylori infection in Sprague Dawley rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Estimates of Cancer Mortality Attributable to Carcinogenic Infections in Italy.International journal of environmental research and public health · 2020
    Article
  17. Laser therapy · 2020
    Article
  18. Article
  19. Protective activity of geraniol against acetic acid andJournal of traditional and complementary medicine · 2019
    Article
  20. Contribution of genetic amplification by PCR for the diagnosis ofUnited European gastroenterology journal · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elizabeth A MarcusDepartment of Pediatrics, DGSOM at UCLA, Los Angeles, CA, USA. emarcus@mednet.ucla.edu.
George SachsDepartment of Physiology, DGSOM at UCLA, Los Angeles, CA, USA.
David R ScottDepartment of Physiology, DGSOM at UCLA, Los Angeles, CA, USA.

Funding

The role of ArsS in gastric infection by Helicobacter pyloriR01DK105156 · NIDDK · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI MARCUS, ELIZABETH A. · 2015 to 2018
$1.1M
Mechanisms of gastric mucosal response to H. pylori infection at acidic pHK08DK100661 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARCUS, ELIZABETH A. · 2014 to 2017
$561k
ROLE OF PROGESTERONE RECEPTOR RATIO IN BREAST CANCERF32CA090073 · NCI · UNIVERSITY OF COLORADO DENVER · PI JACOBSEN, BRITTA M · 2001 to 2003
$127k
Acid Adaptation Targets for Eradication of Helicobacter pyloriI01BX001006 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI SACHS, GEORGE · 2011 to 2018
–
BLRD VA I01 BX001006NCI NIH HHS F32 CA090073NIDDK NIH HHS K08 DK100661NIDDK NIH HHS R01 DK105156
6 · The paper itself

Abstract

Helicobacter pylori infects about 50 % of the world's population, causing at a minimum chronic gastritis. A subset of infected patients will ultimately develop gastric or duodenal ulcer disease, gastric adenocarcinoma, or MALT (mucosa-associated lymphoid tissue) lymphoma. Eradication of H. pylori requires complex regimens that include acid suppression and multiple antibiotics. The efficacy of treatment using what were once considered standard regimens have declined in recent years, mainly due to widespread development of antibiotic resistance. Addition of bismuth to standard triple therapy regimens, use of alternate antibiotics, or development of alternative regimens using known therapies in novel combinations have improved treatment efficacy in specific populations, but overall success of eradication remains less than ideal. Novel regimens under investigation either in vivo or in vitro, involving increased acid suppression ideally with fewer antibiotics or development of non-antibiotic treatment targets, show promise for future therapy.

Indexed as

Helicobacter pyloriAnti-Bacterial AgentsBismuthChronic DiseaseDrug Resistance, BacterialDrug Therapy, CombinationGastritisHelicobacter InfectionsHumansProton Pump InhibitorsAnti-Bacterial AgentsBismuthProton Pump InhibitorsAntibiotic resistanceEradicationGastric acidHelicobacter pylori

Identifiers

PMID27177639
PMCPMC4915378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.