Evidence map›Paper›PMID 27177557›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2016

Coagulation Biomarkers in Healthy Chinese-Origin Rhesus Macaques (Macaca mulatta).

Galit H Frydman, Pavan K Bendapudi, Robert P Marini, Charles R Vanderburg, Ronald G Tompkins, James G Fox

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Galit H FrydmanDivision of Comparative Medicine and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Division of Surgery, Science, and Bioengineering, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. gfrydman@mit.edu.
Pavan K BendapudiDivision of Hematology, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Robert P MariniDivision of Comparative Medicine and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Charles R VanderburgAdvanced Tissue Resource Center, Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
Ronald G TompkinsDivision of Surgery, Science, and Bioengineering, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
James G FoxDivision of Comparative Medicine and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Massachusetts Institute of Technology · US

Funding

WOUND HEALINGP50GM021700 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MARTYN, JEEVENDRA · 1985 to 2017
$27.2M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
NIEHS NIH HHS P30 ES002109NIGMS NIH HHS P50 GM021700NIH HHS T32-OD019078-27
6 · The paper itself

Abstract

Rhesus macaques (Macaca mulatta) are a common model for the study of human biology and disease. To manage coagulopathies in these animals and to study their clotting changes, the ability to measure coagulation biomarkers is necessary. Currently, few options for coagulation testing in NHP are commercially available. In this study, assays for 4 coagulation biomarkers-D-dimer, antithrombin III, protein C, and soluble P-selectin-were developed and optimized for rhesus macaques. Whole blood was collected from 28 healthy Chinese-origin rhesus macaques (11 male; 17 female) ranging in age from 5 to 20 y. Coagulation biomarkers were measured by using bead-based sandwich ELISA technology. The ranges (mean ± 90% confidence interval) for these biomarkers were: antithrombin III, 124.2 to 133.4 μg/mL; protein C, 3.2 to 3.6 μg/mL; D-dimer, 110.3 to 161.3 ng/mL; soluble P-selectin, 0.12 to 0.14 ng/10(6) platelets. These reference values did not differ significantly according to sex or age. These new assays for coagulation biomarkers in rhesus macaques will facilitate the evaluation of in vivo hemostasis.

Indexed as

Blood CoagulationAnimalsBiomarkersEnzyme-Linked Immunosorbent AssayFemaleFibrin Fibrinogen Degradation ProductsHemostasisMacaca mulattaMaleModels, AnimalReference ValuesBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment D

Identifiers

PMID27177557
PMCPMC4865685
OpenAlexW2440714814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.