Evidence map›Paper›PMID 27177440›Full record

ArticleJournal of the American Academy of Dermatology2016

Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations.

Jayasri G Iyer, Kaushik Parvathaneni, Shailender Bhatia, Erica S Tarabadkar, Astrid Blom, Ryan Doumani, Jill McKenzie, Maryam M Asgari, Paul Nghiem

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Paraneoplastic syndromes in patients with melanoma.Postepy dermatologii i alergologii · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jayasri G IyerDermatology Division, Department of Medicine, University of Washington, Seattle, Washington.
Kaushik ParvathaneniDermatology Division, Department of Medicine, University of Washington, Seattle, Washington.
Shailender BhatiaMedical Oncology Division, Department of Medicine, University of Washington, Seattle, Washington.
Erica S TarabadkarDermatology Division, Department of Medicine, University of Washington, Seattle, Washington.
Astrid BlomDermatology Division, Department of Medicine, University of Washington, Seattle, Washington.
Ryan DoumaniDermatology Division, Department of Medicine, University of Washington, Seattle, Washington.
Jill McKenzieDermatology Division, Department of Medicine, University of Washington, Seattle, Washington.
Maryam M AsgariDivision of Research, Kaiser Permanente Northern California, Oakland, California; Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
Paul NghiemDermatology Division, Department of Medicine, University of Washington, Seattle, Washington. Electronic address: pnghiem@uw.edu.
University of Washington · USKaiser Permanente · USUniversity of Washington Medical Center · US

Funding

Pathogenetic and prognostic studies for improved therapy of Merkel cell carcinomaK24CA139052 · NCI · UNIVERSITY OF WASHINGTON · PI NGHIEM, PAUL · 2009 to 2018
$1.8M
Humoral and cellular immunity in polyomavirus-linked Merkel cell carcinomaR01CA162522 · NCI · UNIVERSITY OF WASHINGTON · PI NGHIEM, PAUL · 2011 to 2015
$1.6M
Targeting MCPyV to Overcome Immune Evasion in Merkel Cell CarcinomaRC2CA147820 · NCI · UNIVERSITY OF WASHINGTON · PI NGHIEM, PAUL · 2009 to 2010
$1.0M
NCI NIH HHS K24 CA139052NCI NIH HHS R01 CA162522NCI NIH HHS RC2 CA147820
6 · The paper itself

Abstract

backgroundParaneoplastic syndromes (PNS) are commonly associated with neuroendocrine cancers, such as small cell lung cancer.

objectivesWe examined the association of PNS in Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer.

methodsWe identified PNS associated with MCC based on chart review of a Seattle-based repository and examined the incidence of MCC-associated hyponatremia in an independent cohort within Kaiser Permanente Northern California.

resultsEight PNS cases were identified from the Seattle repository. Three distinct PNS types were observed: cerebellar degeneration (1 case), Lambert-Eaton myasthenic syndrome (2 cases), and malignancy-associated hyponatremia (5 cases). Moreover, the incidence of severe hyponatremia (serum sodium <125 mmol/L) coincident with MCC was identified among 4.3% (9 of 211) patients with MCC in the Kaiser Permanente Northern California cohort. LIMITATIONS: We did not have access to complete medical records on all patients so it was not possible to determine the prevalence of PNS in MCC.

conclusionsMCC can be associated with PNS similar to those found in other neuroendocrine cancers. Clinicians should be aware of these presentations as PNS often precede the identification of the underlying malignancy and usually resolve with appropriate treatment of the cancer.

Indexed as

AgedAged, 80 and overAge DistributionCarcinoma, Merkel CellComorbidityDisease-Free SurvivalFemaleHumansIncidenceMaleMiddle AgedParaneoplastic SyndromesPrognosisRegistriesRisk AssessmentSampling Studiescerebellar degenerationLambert-Eaton myasthenic syndromemalignancy-associated hyponatremiaMerkel cell carcinomaneuroendocrineparaneoplastic syndrome

Identifiers

PMID27177440
PMCPMC4992627
OpenAlexW2387676003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.