ArticlePloS one2016
Early-Onset Thrombocytopenia in Small-For-Gestational-Age Neonates: A Retrospective Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Peripheral blood cell counts of prematurely born, small for gestational age neonates.Clinical and experimental pediatrics · 2026Article
- Article
- Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia.BMC pregnancy and childbirth · 2025Article
- Hemostatic Profile of Intrauterine Growth-Restricted Neonates: Assessment with the Use of NATEM Assay in Cord Blood Samples.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Neonatal hematological parameters: the translational aspect of developmental hematopoiesis.Annals of hematology · 2023Review
- Thrombocytopenia and insufficient thrombopoietin production in human small-for-gestational-age infants.Pediatric research · 2023Article
- The effects of maternal hypertension on the early neonatal platelet count.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Primary hemostasis in fetal growth restricted neonates studiedFrontiers in pediatrics · 2022Article
- Article
- Leukocyte Counts and Other Hematological Values in Twin-Twin Transfusion Syndrome and Twin Anemia-Polycythemia Sequence.Fetal diagnosis and therapy · 2020Article
- Neonatal thrombocytopenia-causes and outcomes following platelet transfusions.European journal of pediatrics · 2018Article
- Ranitidine-induced Thrombocytopenia in a Neonate - A Case Report and Review of Literature.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thrombocytopenia is a common finding in small for gestational age (SGA) neonates and is thought to result from a unique pathophysiologic mechanism related to chronic intrauterine hypoxia. Our objective was to estimate the incidence and severity of early-onset thrombocytopenia in SGA neonates, and to identify risk factors for thrombocytopenia. We performed a retrospective cohort study of all consecutive SGA neonates admitted to our ward and a control group of appropriate for gestational age (AGA) neonates matched for gestational age at birth. Main outcome measures were incidence and severity of thrombocytopenia, hematological and clinical risk factors for thrombocytopenia, and bleeding. A total of 330 SGA and 330 AGA neonates were included, with a mean gestational age at birth of 32.9 ± 4 weeks. Thrombocytopenia (<150x10(9)/L) was found in 53% (176/329) of SGA neonates and 20% (66/330) of AGA neonates (relative risk (RR) 2.7, 95% confidence interval (CI) [2.1, 3.4]). Severe thrombocytopenia (21-50x10(9)/L) occurred in 25 neonates (8%) in the SGA and 2 neonates (1%) in the AGA group (RR 12.5, 95% CI [3.0, 52.5]). Platelet counts <20x10(9)/L were not recorded. Within the SGA group, lower gestational age at birth (p = <0.01) and erythroblastosis (p<0.01) were independently associated with a decrease in platelet count. Platelet count was positively correlated with birth weight centiles. In conclusion, early-onset thrombocytopenia is present in over 50% of SGA neonates and occurs 2.7 times as often as in AGA neonates. Thrombocytopenia is seldom severe and is independently associated with lower gestational age at birth and erythroblastosis.
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