Evidence map›Paper›PMID 27176965›Full record

ArticleOptics letters2016

Polarization sensitive optical coherence microscopy for brain imaging.

Hui Wang, Taner Akkin, Caroline Magnain, Ruopeng Wang, Jay Dubb, William J Kostis, Mohammad A Yaseen, Avilash Cramer, Sava Sakadžić, David Boas

Open access · greenAbstract read
In one paragraph

Article in Optics letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 102 citations in OpenAlex.

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  9. Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hui Wang
Taner Akkin
Caroline Magnain
Ruopeng Wang
Jay Dubb
William J Kostis
Mohammad A Yaseen
Avilash Cramer
Sava Sakadžić
David Boas
Athinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · USHarvard University · USUniversity of Minnesota · US

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular ChangesR01EB021018 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2015 to 2018
$2.9M
Two-Photon Microscopy of Oxygen Consumption in the BrainR01NS091230 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SAKADZIC, SAVA · 2015 to 2019
$2.4M
Dendritic upconverting nanoparticles for multiphoton imaging and sensingR01EB018464 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2014 to 2017
$1.5M
In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime MicroscopyR00AG042026 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YASEEN, MOHAMMAD ABBAS · 2015 to 2017
$747k
In Vivo Imaging Alzheimers Disease Pathology with 2-Photon/Lifetime MicroscopyK99AG042026 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YASEEN, MOHAMMAD ABBAS · 2013 to 2014
$274k
NIA NIH HHS K99 AG042026NIA NIH HHS R00 AG042026NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB018464NIBIB NIH HHS R01 EB021018NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS091230
6 · The paper itself

Abstract

Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 μm axial and 1.3 μm transverse resolution to investigate fiber organization and orientation at a finer scale than previously demonstrated with PS-OCT. In a reconstructed mouse brain section, we showed that at the focal depths of 20-70 μm, the PS-OCM reliably identifies the neuronal fibers and quantifies the in-plane orientation.

Indexed as

AnimalsBirefringenceBrainMiceMicroscopy, PolarizationNeuroimagingTomography, Optical Coherence

Identifiers

PMID27176965
PMCPMC5357322
OpenAlexW2346595684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.