ArticleAstrobiology2016
Enzymatic Antioxidant Systems in Early Anaerobes: Theoretical Considerations.
Article in Astrobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
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- Surviving desiccation: key factors underlying tolerance in prokaryotes and eukaryotes.Protoplasma · 2025Review
- A Nanosystem Alleviates Severe Acute Pancreatitis via Reactive Oxygen Species Scavenging and Enhancing Mitochondrial Autophagy.Nano letters · 2025Article
- Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology.Frontiers in chemistry · 2024Review
- Optimization and Enhancement of the Peroxidase-like Activity of Hemin in Aqueous Solutions of Sodium Dodecylsulfate.ACS omega · 2023Article
- Application of Spectroscopic Methods for the Identification of Superoxide Dismutases in Cyanobacteria.International journal of molecular sciences · 2022Article
- Characterization of ancestral Fe/Mn superoxide dismutases indicates their cambialistic origin.Protein science : a publication of the Protein Society · 2022Article
- Functionalized Prussian Blue Nanozyme as Dual-Responsive Drug Therapeutic Nanoplatform Against Maxillofacial Infection via Macrophage Polarization.International journal of nanomedicine · 2022Article
- Thriving in Oxygen While Preventing ROS Overproduction: No Two Systems Are Created Equal.Frontiers in physiology · 2022Review
- Methionine Sulfoxide Reductases Contribute to Anaerobic Fermentative Metabolism inAntioxidants (Basel, Switzerland) · 2021Article
- Elemental iron modifies the redox environment of the gastrointestinal tract: A novel therapeutic target and test for metabolic syndrome.Free radical biology & medicine · 2021Article
- How Microbes Evolved to Tolerate Oxygen.Trends in microbiology · 2021Review
- The evolution of oxygen-utilizing enzymes suggests early biosphere oxygenation.Nature ecology & evolution · 2021Article
- Sulfur Chemistry May Have Paved the Way for Evolution of Antioxidants.Astrobiology · 2020Article
- On the origin of microbial magnetoreception.National science review · 2020Article
- Aerobic prokaryotes do not have higher GC contents than anaerobic prokaryotes, but obligate aerobic prokaryotes have.BMC evolutionary biology · 2019Article
- A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging.Antioxidants & redox signaling · 2018Review
- Methionine Sulfoxide Reductases of Archaea.Antioxidants (Basel, Switzerland) · 2018Review
- RETRACTED ARTICLE: The quantum physiology of oxygen; from electrons to the evolution of redox signaling in the human brain.Bioelectronic medicine · 2018Review
- The Complex Transcriptional Response ofG3 (Bethesda, Md.) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIt is widely accepted that cyanobacteria-dependent oxygen that was released into Earth's atmosphere ca. 2.5 billion years ago sparked the evolution of the aerobic metabolism and the antioxidant system. In modern aerobes, enzymes such as superoxide dismutases (SODs), peroxiredoxins (PXs), and catalases (CATs) constitute the core of the enzymatic antioxidant system (EAS) directed against reactive oxygen species (ROS). In many anaerobic prokaryotes, the superoxide reductases (SORs) have been identified as the main force in counteracting ROS toxicity. We found that 93% of the analyzed strict anaerobes possess at least one antioxidant enzyme, and 50% have a functional EAS, that is, consisting of at least two antioxidant enzymes: one for superoxide anion radical detoxification and another for hydrogen peroxide decomposition. The results presented here suggest that the last universal common ancestor (LUCA) was not a strict anaerobe. O2 could have been available for the first microorganisms before oxygenic photosynthesis evolved, however, from the intrinsic activity of EAS, not solely from abiotic sources. KEY WORDS: Archaea-Atmospheric gases-Evolution-H2O2 resistance-Oxygenic photosynthesis. Astrobiology 16, 348-358.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.