ArticleBehavioral neuroscience2016
Social play in juvenile hamsters alters dendritic morphology in the medial prefrontal cortex and attenuates effects of social stress in adulthood.
Article in Behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- From welfare indicator to welfare contributor: the role of play in building flexibility and resilience in captive animals.Proceedings. Biological sciences · 2025Review
- Does Play After Training Improve a Canine Good Citizenship Skill in Pet Dogs?Animals : an open access journal from MDPI · 2025Article
- Nuancing 'Emotional' Social Play: Does Play Behaviour Always Underlie a Positive Emotional State?Animals : an open access journal from MDPI · 2024Review
- Play partner preferences among groups of unfamiliar juvenile male rats.Scientific reports · 2024Article
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- A tool to act blind? Object-assisted eye-covering as a self-handicapping behavior and social play signal in Balinese long-tailed macaques.Animal cognition · 2023Article
- Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females.Frontiers in behavioral neuroscience · 2022Article
- Behavioral and hormonal changes following social instability in young rhesus macaques (Macaca mulatta).Journal of comparative psychology (Washington, D.C. : 1983) · 2021Article
- Evolution of stress responses refine mechanisms of social rank.Neurobiology of stress · 2021Review
- Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice.Neuroscience bulletin · 2020Article
- Play in Elephants: Wellbeing, Welfare or Distraction?Animals : an open access journal from MDPI · 2020Article
- Social and olfactory experiences modify neuronal morphology of orbital frontal cortex.Behavioral neuroscience · 2020Article
- Therapeutic efficacy of environmental enrichment for substance use disorders.Pharmacology, biochemistry, and behavior · 2020Review
- Development of social play in hamsters: Sex differences and their possible functions.Brain research · 2019Article
- Effects of neonatal handling on play and anxiety in F344 and Lewis rats.Developmental psychobiology · 2018Article
- Toward a Theory of the Evolution of Fair Play.Frontiers in psychology · 2018Article
- Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex.Frontiers in behavioral neuroscience · 2018Article
- What is play fighting and what is it good for?Learning & behavior · 2017Article
- The relationship between social play and developmental milestones in wild chimpanzees (Pan troglodytes schweinfurthii).American journal of primatology · 2017Article
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Authors and funding
6 authors at 1 institution in 3 countries.
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Abstract
Social play is a fundamental aspect of behavioral development in many species. Social play deprivation in rats alters dendritic morphology in the ventromedial prefrontal cortex (vmPFC) and we have shown that this brain region regulates responses to social defeat stress in Syrian hamsters. In this study, we tested whether play deprivation during the juvenile period disrupts dendritic morphology in the prefrontal cortex and potentiates the effects of social defeat stress. At weaning, male hamsters were either group-housed with peers or pair-housed with their mother, with whom they do not play. In adulthood, animals received acute social defeat stress or no-defeat control treatment. The hamsters were then tested for a conditioned defeat response in a social interaction test with a novel intruder, and were also tested for social avoidance of a familiar opponent. Brains were collected for Golgi-Cox staining and analysis of dendritic morphology in the infralimbic (IL), prelimbic (PL), and orbitofrontal cortex (OFC). Play-deprived animals showed an increased conditioned defeat response and elevated avoidance of a familiar opponent compared with play-exposed animals. Furthermore, play-deprived animals showed increased total length and branch points in apical dendrites of pyramidal neurons in the IL and PL cortices, but not in the OFC. These findings suggest that social play deprivation in juvenile hamsters disrupts neuronal development in the vmPFC and increases vulnerability to the effects of social stress in adulthood. Overall, these results suggest that social play is necessary for the natural dendritic pruning process during adolescence and promotes coping with stress in adulthood. (PsycINFO Database Record
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