Evidence map›Paper›PMID 27176005›Full record

Trial reportBMC urology2016

A novel stepwise micro-TESE approach in non obstructive azoospermia.

Giorgio Franco, Filomena Scarselli, Valentina Casciani, Cosimo De Nunzio, Donato Dente, Costantino Leonardo, Pier Francesco Greco, Alessia Greco, Maria Giulia Minasi, Ermanno Greco

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
8.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 64 citations in OpenAlex.

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  20. Sertoli cell-only syndrome: etiology and clinical management.Journal of assisted reproduction and genetics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Giorgio FrancoDepartment Gynaecological-Obstetrical and Urological Sciences, Sapienza University, via del Policlinico n 155 cap, 00161, Rome, Italy.
Filomena ScarselliCentre for Reproductive Medicine, European Hospital, Rome, Italy.
Valentina CascianiCentre for Reproductive Medicine, European Hospital, Rome, Italy.
Cosimo De NunzioDepartment Urology, Sant' Andrea Hospital, Sapienza University, Rome, Italy.
Donato DenteRobotic Urology Department, Policlinico Abano Terme, Padova, Italy.
Costantino LeonardoDepartment Gynaecological-Obstetrical and Urological Sciences, Sapienza University, via del Policlinico n 155 cap, 00161, Rome, Italy. costantino.leonardo@gmail.com.
Pier Francesco GrecoCentre for Reproductive Medicine, European Hospital, Rome, Italy.
Alessia GrecoCentre for Reproductive Medicine, European Hospital, Rome, Italy.
Maria Giulia MinasiCentre for Reproductive Medicine, European Hospital, Rome, Italy.
Ermanno GrecoCentre for Reproductive Medicine, European Hospital, Rome, Italy.
European Hospital · ITPoliclinico Umberto I · ITAzienda Ospedaliera Sant'Andrea · ITPoliclinico Abano Terme · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by employing a novel stepwise micro-TESE approach in a population of poor prognosis patients with non-obstructive azoospermia (NOA).

methodsSixty-four poor prognosis NOA men undergoing surgical testicular sperm retrieval for ICSI, from March 2007 to April 2013, were included in this study. Patients inclusion criteria were a) previous unsuccessful TESE, b) unfavorable histology (SCOS, MA, sclerahyalinosis), c) Klinefelter syndrome. We employed a stepwise micro-TESE consisting three-steps: 1) single conventional TESE biopsy; 2) micro-TESE on the same testis; 3) contralateral multiple TESE.

resultsSRR was 28.1 % (18/64). Sperm was obtained in both the initial single conventional TESE and in the following micro-TESE. The positive or negative sperm retrieval was further confirmed by a contralateral multiple TESE, when performed. No significant pre-operative predictors of sperm retrieval, including patients' age, previous negative TESE or serological markers (LH, FSH, inhibin B), were observed at univariate or multivariate analysis. Micro-TESE (step 2) did not improve sperm retrieval as compared to single TESE biopsy on the same testicle (step 1) or multiple contralateral TESE (step 3).

conclusionsStepwise micro-TESE could represent an optimal approach for sperm retrieval in NOA men. In our view, it should be offered to NOA patients in order to gradually increase surgical invasiveness, when necessary. Stepwise micro-TESE might also reduce the costs, time and efforts involved in surgery.

Indexed as

Sperm RetrievalAdultAzoospermiaBiopsyHumansMaleMicrosurgerySpermatozoaTestisAzoospermiaICSIMicro-TESESperm retrievalTESE

Identifiers

PMID27176005
PMCPMC4866333
OpenAlexW2366008778

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.