SynthesisMedicine2016
The Effect of Subclinical Maternal Thyroid Dysfunction and Autoimmunity on Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis.
Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review.BMC pregnancy and childbirth · 2026Pooled it
- Autoimmune diseases and adverse pregnancy outcomes: an umbrella review.BMC medicine · 2024Pooled it
- Maternal Thyroid Dysfunction and Gestational Anemia Risk: Meta-Analysis and New Data.Frontiers in endocrinology · 2020Pooled it
- Hypothyroidism and related diseases: a methodological quality assessment of meta-analysis.BMJ open · 2019Pooled it
- Meta-analysis of ART outcomes in women with different preconception TSH levels.Reproductive biology and endocrinology : RB&E · 2018Pooled it
- Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study.BMC pregnancy and childbirth · 2022Trial
- Trial
- The Heart of Fetal Growth Restriction: Congenital Heart Defects-An Analysis of Risk Factors and Morbidity Outcomes.Life (Basel, Switzerland) · 2026Article
- Article
- The Effects of Maternal Subclinical Hypothyroidism on Fetal Thymus Size: A Prospective Study.Diagnostics (Basel, Switzerland) · 2025Article
- The maternal factors during pregnancy for intrauterine growth retardation: An umbrella review.Open medicine (Warsaw, Poland) · 2025Review
- Pregnancy outcome in subclinical hypothyroidism with and without thyroid peroxidase antibodies-a prospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Gestation-suppressed serum TSH levels during early pregnancy are not associated with altered maternal and neonatal outcomes.European thyroid journal · 2023Article
- Maternal preconception thyroid autoimmunity is associated with neonatal birth weight conceived by PCOS women undergoing their first in vitro fertilization/intracytoplasmic sperm injection.Journal of ovarian research · 2023Article
- Prenatal exposure to tap water containing nitrate and the risk of small-for-gestational-age: A nationwide register-based study of Danish births, 1991-2015.Environment international · 2023Article
- Management of Hyperthyroidism during Pregnancy: A Systematic Literature Review.Journal of clinical medicine · 2023Review
- Maternal Subclinical Hyperthyroidism and Adverse Pregnancy Outcomes: A Systematic Review and Meta-analysis of Observational Studies.International journal of endocrinology and metabolism · 2022Article
- Article
- Rs868058 in the Homeobox GeneBiology · 2022Article
- Laboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study.Bioengineered · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the association between maternal subclinical thyroid dysfunction and autoimmunity with the risk for intrauterine growth restriction (IUGR).Design is a systematic review and meta-analysis.A literature search was conducted using PubMed, Embase, and Cochrane database. A combination of 2 key words was used to search for the eligible studies: one indexed thyroid dysfunction or antithyroid antibodies; and the other one indexed the adverse neonatal outcomes of pregnancy, such as IUGR, small for gestational age, fetal growth restriction, or low birth weight.Two reviewers selected the studies, and eligible studies met the following criteria: prospective cohort studies or case control studies, studies of maternal thyroid dysfunction and positive antithyroid antibodies as the exposure of interest, and studies of IUGR or small for gestational age as the outcome of interest.Data were recorded, including data from maternal thyroid disorders and IUGR, and compared with a reference group.There were 22 individual data from the 13 cohort articles. Among these, 7 were focused on subclinical hypothyroidism (SCH), 4 on subclinical hyperthyroidism, 7 on positivity for thyroid peroxidase antibody (TPOAb), and 4 on isolated hypothyroxinemia. Meta-analysis showed that there was no effect of subclinical hyperthyroidism (odds ratio (OR) = 0.98; 95% confidence interval (CI), 0.40-2.41), TPOAb positivity (OR = 1.57; 95% CI, 0.77-3.18), or isolated hypothyroxinemia (OR = 1.05, 95% CI: 0.37-2.92) on IUGR. However, SCH is associated with IUGR (OR = 1.54; 95% CI, 1.06-2.25).SCH is associated with IUGR; however, subclinical hyperthyroidism, TPOAb positivity, or isolated hypothyroxinemia do not affect the risk of IUGR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.