Evidence map›Paper›PMID 27175443›Full record

ArticleACS biomaterials science & engineering2015

Biodegradable PEG-Based Amphiphilic Block Copolymers for Tissue Engineering Applications.

Artem B Kutikov, Jie Song

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Artem B KutikovDepartment of Orthopedics and Physical Rehabilitation. University of Massachusetts Medical School. 55 Lake Ave North, Worcester, MA 01655, USA.
Jie SongDepartment of Orthopedics and Physical Rehabilitation. University of Massachusetts Medical School. 55 Lake Ave North, Worcester, MA 01655, USA; Department of Cell and Developmental Biology. University of Massachusetts Medical School. 55 Lake Ave North, Worcester, MA 01655, USA.

Funding

Osteogenic synthetic bone grafts for the repair of musculoskeletal defectsR01AR055615 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SONG, JIE · 2008 to 2012
$1.4M
A nanostructured approach to complex tissue scaffolds and smart implantsR01GM088678 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SONG, JIE · 2009 to 2012
$1.3M
NIAMS NIH HHS R01 AR055615NIGMS NIH HHS R01 GM088678
6 · The paper itself

Abstract

Biodegradable tissue engineering scaffolds have great potential for delivering cells/therapeutics and supporting tissue formation. Polyesters, the most extensively investigated biodegradable synthetic polymers, are not ideally suited for diverse tissue engineering applications due to limitations associated with their hydrophobicity. This review discusses the design and applications of amphiphilic block copolymer scaffolds integrating hydrophilic poly(ethylene glycol) (PEG) blocks with hydrophobic polyesters. Specifically, we highlight how the addition of PEG results in striking changes to the physical properties (swelling, degradation, mechanical, handling) and biological performance (protein & cell adhesion) of the degradable synthetic scaffolds

Indexed as

amphiphilic polymersbiodegradableblock copolymerspoly(ethylene glycol) (PEG)tissue engineering scaffolds

Identifiers

PMID27175443
PMCPMC4860614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.