ArticleActa pharmaceutica Sinica. B2016
Parishin C's prevention of Aβ 1-42-induced inhibition of long-term potentiation is related to NMDA receptors.
Article in Acta pharmaceutica Sinica. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Bletistrosides M-X, Anti-Alzheimer's Disease Compounds from the Tubers ofJournal of natural products · 2025Article
- Chemoprofiling of Himantoglossum robertianum (Loisel.) P. Delforge leaves reveals predominance of gastrodigenin and structurally related compounds.Natural products and bioprospecting · 2025Article
- Genome-wide identification of carboxyesterase family members reveals the function of GeCXE9 in the catabolism of parishin A in Gastrodia elata.Plant cell reports · 2025Article
- From molecules to medicine: a systematic review of Gastrodia elata's bioactive metabolites and therapeutic potential.Frontiers in pharmacology · 2025Review
- Sleep promoting and omics exploration on probiotics fermented Gastrodia elata Blume.NPJ science of food · 2024Article
- Parishin A-loaded mesoporous silica nanoparticles modulate macrophage polarization to attenuate tendinopathy.NPJ Regenerative medicine · 2023Article
- Specific gut microbiome and metabolome changes in patients with continuous ambulatory peritoneal dialysis and comparison between patients with different dialysis vintages.Frontiers in medicine · 2023Article
- pH as a Key Factor for the Quality Assurance of the Preparation ofMolecules (Basel, Switzerland) · 2022Article
- Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder.Acta pharmaceutica Sinica. B · 2021Review
- Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata.Natural products and bioprospecting · 2021Article
- Ameliorative Effect of Parishin C Against Cerebral Ischemia-Induced Brain Tissue Injury by Reducing Oxidative Stress and Inflammatory Responses in Rat Model.Neuropsychiatric disease and treatment · 2021Article
- Indole alkaloid glycosides with a 1'-(phenyl)ethyl unit fromActa pharmaceutica Sinica. B · 2020Article
- Metabolite Profiling and Distribution of Militarine in Rats Using UPLC-Q-TOF-MS/MS.Molecules (Basel, Switzerland) · 2020Article
- Transformation Mechanisms of Chemical Ingredients in Steaming Process ofMolecules (Basel, Switzerland) · 2019Article
- Optimal Extraction Study of Gastrodin-Type Components fromMolecules (Basel, Switzerland) · 2019Article
- Sulfur-enriched alkaloids from the root ofActa pharmaceutica Sinica. B · 2018Article
- CActa pharmaceutica Sinica. B · 2018Article
- 8,4'-Oxyneolignane glucosides from an aqueous extract of "ban lan gen" (Acta pharmaceutica Sinica. B · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rhizome of Gastrodia elata (GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ 1-42 oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ 1-42 oligomer-injected rats and the underlying electrophysiological mechanisms. Parishin C (i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ 1-42 oligomers. In cultured hippocampal neurons, soluble Aβ 1-42 oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ 1-42 oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors.
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