Evidence map›Paper›PMID 27175293›Full record

ArticleRMD open2016

Malignancy incidence in 5294 patients with juvenile arthritis.

Omid Zahedi Niaki, Ann E Clarke, Rosalind Ramsey-Goldman, Rae Yeung, Kristen Hayward, Kiem Oen, Ciarán M Duffy, Alan Rosenberg, Kathleen M O'Neil, Emily von Scheven and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 2 countries.

Omid Zahedi NiakiDepartment of Medicine , McGill University , Montreal, Quebec , Canada.
Ann E ClarkeDepartment of Medicine , University of Calgary , Calgary, Alberta , Canada.
Rosalind Ramsey-GoldmanNorthwestern University, Feinberg School of Medicine , Chicago, Illinois , USA.
Rae YeungDivision of Rheumatology , The Hospital for Sick Children , Toronto, Ontario , Canada.
Kristen HaywardDepartment of Rheumatology , Seattle Children's Hospital , Seattle, Washington , USA.
Kiem OenDepartment of Pediatrics , University of Manitoba , Winnipeg, Manitoba , Canada.
Ciarán M DuffyDepartment of Pediatrics , Children's Hospital of Eastern Ontario , Ottawa, Ontario , Canada.
Alan RosenbergDepartment of Pediatrics , Royal University Hospital , Saskatoon, Saskatchewan , Canada.
Kathleen M O'NeilDivision of Pediatric Rheumatology , Riley Hospital for Children , Indianapolis, Indiana , USA.
Emily von SchevenDepartment of Pediatric Rheum San Francisco , University of California , San Francisco, California , USA.
Laura SchanbergDepartment of Pediatrics , Duke University Medical Center , Durham, North Carolina , USA.
Jeremy LabrecqueDepartment of Medicine , McGill University , Montreal, Quebec , Canada.
Shirley M L TseDivision of Rheumatology , The Hospital for Sick Children , Toronto, Ontario , Canada.
Rachana HasijaDivision of Rheumatology , The Hospital for Sick Children , Toronto, Ontario , Canada.
Jennifer L F LeeDepartment of Medicine , McGill University , Montreal, Quebec , Canada.
Sasha BernatskyDepartment of Medicine, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
McGill University · CAHospital for Sick Children · CAChildren's Hospital of Eastern Ontario · CADuke Medical Center · USNorthwestern University · USRiley Hospital for Children · USRoyal University Hospital · CASeattle Children's Hospital · USUniversity of Calgary · CAUniversity of California, San Francisco · USUniversity of Manitoba · CA

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
NCATS NIH HHS UL1 TR001422
6 · The paper itself

Abstract

objectiveTo determine cancer incidence in a large clinical juvenile-onset arthritis population.

methodsWe combined data from 6 existing North American juvenile-onset arthritis cohorts. Patients with juvenile-onset arthritis were linked to regional cancer registries to detect incident cancers after cohort entry, defined as first date seen in the paediatric rheumatology clinic. The expected number of malignancies was obtained by multiplying the person-years observed (defined from cohort entry to end of follow-up) by the geographically matched age, sex and calendar year-specific cancer rates. The standardised incidence ratios (SIR; ratio of cancers observed to expected) were generated, with 95% CIs.

resultsThe 6 juvenile arthritis registries provided a total of 5294 patients. The mean age at cohort entry was 8.9 (SD 5.0) years and 68% of participants were female. The mean duration of follow-up was 6.8 years with a total of 36 063 person-years spanning 1978-2012. During follow-up, 9 invasive cancers occurred, compared with 10.9 expected (SIR 0.82, 95% CI 0.38 to 1.5). 3 of these were haematological (Hodgkin's, non-Hodgkin's lymphoma and leukaemia). 6 of the patients with cancer were exposed to disease-modifying drugs; 5 of these had also been exposed to biological agents.

conclusionsWe did not clearly demonstrate an increase in overall malignancy risk in patients with juvenile-onset arthritis followed for an average of almost 7 years. 3 of the 9 observed cancers were haematological. 5 of the cancers arose in children exposed to biological agents. Longer follow-up of this population is warranted, with further study of drug effects.

Indexed as

ArthritisEpidemiologyJuvenile Idiopathic Arthritis

Identifiers

PMID27175293
PMCPMC4860862
OpenAlexW2346746425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.