Evidence map›Paper›PMID 27175281›Full record

ArticleTranslational neurodegeneration2016

Clinical characteristics of fatigued Parkinson's patients and the response to dopaminergic treatment.

Rao Fu, Xiao-Guang Luo, Yan Ren, Zhi-Yi He, Hong Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. The Parkinson fatigue scale: an evaluation of its validity and reliability in Greek Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rao FuNeurology Department, Outpatient of Parkinson's Disease, First Affiliated Hospital of China Medical University, 155# Nanjing bei street, Heping District Shenyang, 110001 P R China.
Xiao-Guang LuoNeurology Department, Outpatient of Parkinson's Disease, First Affiliated Hospital of China Medical University, 155# Nanjing bei street, Heping District Shenyang, 110001 P R China.
Yan RenNeurology Department, Outpatient of Parkinson's Disease, First Affiliated Hospital of China Medical University, 155# Nanjing bei street, Heping District Shenyang, 110001 P R China.
Zhi-Yi HeNeurology Department, Outpatient of Parkinson's Disease, First Affiliated Hospital of China Medical University, 155# Nanjing bei street, Heping District Shenyang, 110001 P R China.
Hong LvNeurology Department, Outpatient of Parkinson's Disease, First Affiliated Hospital of China Medical University, 155# Nanjing bei street, Heping District Shenyang, 110001 P R China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue, which is commonly observed in Parkinson's disease (PD), can greatly reduce quality of life and is difficult to treat. We here aimed to investigate the prevalence and characteristics of fatigue among PD patients and to explore an effective strategy to treat PD fatigue.

methodThis was an observational cross-sectional study conducted in northeastern China. We examined fatigue in 222 PD patients from northeastern China using the Parkinson Fatigue Scale-16 (PFS-16). The disease severity, depression, sleep and cognitive functioning were assessed with the Hoehn & Yahr staging (H-Y stage), Unified Parkinson's Disease Rating Scale (UPDRS), Hamilton Depression Scale (HAMD), Parkinson's Disease Sleep Scale (PDSS) and Montreal Cognitive Assessment (MoCA) by interview.

resultsThe frequency of fatigue in PD patients was 59.46 %. Fatigued patients had longer disease durations and greater disease severity than nonfatigued patients. Additionally, fatigued PD patients scored significantly higher for all motor symptoms, except for tremor, and had more serious depressive symptoms and sleep disturbances than nonfatigued PD patients did. The sleep disturbance severity was an independent factor for fatigue. Furthermore, 43.04 % of fatigued patients taking dopaminergic drugs had fatigue remission. Depression severity was identified as an independent factor for dopaminergic drug non-responsive fatigue.

conclusionsPD patients with severe sleep disturbances tend to suffer from fatigue. Levodopa improved fatigue only in PD patients with mild depression or no depression, implying that dopaminergic medication is required, but not sufficient, for fatigue suppression in PD patients with moderate or severe depression. Thus, restoring serotonergic neurotransmission as a combination therapy may offer a better strategy for the treatment of fatigue in these patients.

Indexed as

DepressionDopaminergic drugsFatigueParkinson’s diseaseSleep disorder

Identifiers

PMID27175281
PMCPMC4863328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.