Evidence map›Paper›PMID 27175221›Full record

ArticleNPG Asia materials2015

Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants.

Chi Hwan Lee, Hojun Kim, Daniel V Harburg, Gayoung Park, Yinji Ma, Taisong Pan, Jae Soon Kim, Na Yeon Lee, Bong Hoon Kim, Kyung-In Jang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPG Asia materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Designing the Next Generation of Biomaterials through Nanoengineering.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
  5. Article
  6. Article
  7. Recent Advances in Superhydrophobic Materials Development for Maritime Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Review
  9. Hollow anatase TiOChemical science · 2024
    Article
  10. Article
  11. Article
  12. Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. A Resonant Coupler for Subcutaneous Implant.Sensors (Basel, Switzerland) · 2021
    Article
  16. Polymer-Lipid Hybrid Materials.Chemical reviews · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chi Hwan LeeWeldon School of Biomedical Engineering and School of Mechanical Engineering and The Center for Implantable Devices and Birck Nanotechnology Center, Purdue University, West Lafayette, IN, USA; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Hojun KimDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Daniel V HarburgDepartment of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Gayoung ParkDepartment of Biomicrosystem Technology, Korea University, Seoul, Republic of Korea; Department of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea.
Yinji MaDepartment of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA; Center for Mechanics and Materials, Tsinghua University, Beijing, China.
Taisong PanDepartment of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA; State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Sichuan, China.
Jae Soon KimDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Na Yeon LeeDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Bong Hoon KimDepartment of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kyung-In JangDepartment of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Seung-Kyun KangDepartment of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yonggang HuangDepartment of Civil and Environmental Engineering, and Mechanical Engineering, Center for Engineering and Health and Skin Disease Resesarch Center, Northwestern University, Evanston, IL, USA.
Jeongmin KimDepartment of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea.
Kyung-Mi LeeDepartment of Biochemistry and Molecular Biology, Global Research Laboratory, Korea University College of Medicine, Seoul, Republic of Korea.
Cecilia LealDepartment of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
John A RogersDepartment of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Funding

SCH: Interface Monitoring System to Promote Residual Limb HealthR01EB019337 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COLEMAN, TODD P, FATONE, STEFANIA · 2014 to 2017
$1.5M
NIBIB NIH HHS R01 EB019337
6 · The paper itself

Abstract

On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal.

Identifiers

PMID27175221
PMCPMC4861403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.