ArticleIranian journal of veterinary research2014
Polymorphism of sheep POU1F1 gene exon 6 and 3'UTR region and their association with milk production traits.
Article in Iranian journal of veterinary research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- From candidate genes to whole-genome approaches: current insights into the genetic architecture of ovine milk production and quality traits.Veterinary and animal science · 2026Review
- Association of DGAT1 and POU1F1 Gene Polymorphisms With the Milk Traits in the Cross-Bred Hamdani Sheep Bred Under Extensive Management.Veterinary medicine and science · 2025Article
- Genetic Characterization of Myf5 and POU1F1 Genes in Different Egyptian Local Rabbit Breeds and Their Association with Growth Traits.Biochemical genetics · 2024Article
- Milk-y Way: the impact of single-nucleotide polymorphisms on milk production traits in Kilis dairy goats.Archives animal breeding · 2023Article
- Relationship of Polymorphisms of the Mutation (225131) of theArchives of Razi Institute · 2022Article
- A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis.Journal of mammary gland biology and neoplasia · 2021Review
- Detection of a 4 bp Mutation in the 3'UTR Region of GoatAnimals : an open access journal from MDPI · 2020Article
- Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Animals : an open access journal from MDPI · 2019Review
- Relationship between SNPs ofAnimals : an open access journal from MDPI · 2019Article
- Associations between genetic variants of theArchives animal breeding · 2019Article
- Genome-Wide Association Studies Identify Candidate Genes for Coat Color and Mohair Traits in the Iranian Markhoz Goat.Frontiers in genetics · 2018Article
- A genome scan for milk production traits in dairy goats reveals two new mutations in Dgat1 reducing milk fat content.Scientific reports · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the study was to detect the AluI and DdeI polymorphisms within POU1F1 gene exon 6 and 3'UTR region in Turkish sheep breeds, and their association with milk productive traits. Jugular blood samples were collected from 50 Sakiz, 50 White Karaman, and 50 Awassi sheep using EDTA as an anticoagulant. PCR-RFLP and sequencing analysis were performed to investigate possible polymorphisms in the exon 6 and 3' flanking region of the sheep POU1F1 gene. The PCR products were digested with restriction endonuclease AluI and DdeI, and biallelic polymorphism was found with restriction endonuclease AluI and two genotypes (TT (296 bp and 173 bp) and CC (235 bp, 173 bp and 61 bp)) were detected. White Karaman and Awassi breeds did not show polymorphisms for AluI restriction sites. No polymorphism at the DdeI cleavage sites was detected in the three sheep breeds. Significant statistical results were found in milk yield ((***)P0.001), fat ((***)P0.001) and lactose ((*)P0.05) values with TT and CC genotypes, however no significant association of TT and CC genotypes with protein values was detected (P>0.05) and individuals with genotype TT had a superior milk yield in Sakiz sheep breeds. As sequence results, seven variation points were determined for exon 6 (g.185T>C) and 3'UTR (g.220G>A, g.229C>T, g.248C>T, g.250A>T, g.255T>C, g.258C>T) of the sheep POU1F1 gene. We have reported here for the first time single nucleotide polymorphisms of the POU1F1 gene for both exon 6 and 3'UTR and its effects on milk traits in Turkish sheep breeds were evaluated.
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27175126PMC4789208W2144909280What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.