ArticleIntestinal research2016
Wernicke's encephalopathy after total parenteral nutrition in patients with Crohn's disease.
Article in Intestinal research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Testing-Yield Mismatch in Inpatient Micronutrient Assessment in Inflammatory Bowel Disease: A Real-World Implementation-Gap Analysis.Nutrients · 2026Article
- Novel XIAP mutation with early-onset Crohn's disease complicated with acute heart failure: a case report.BMC cardiovascular disorders · 2023Article
- A Case Report of Nonalcoholic Gayet-Wernicke Encephalopathy: Don't Miss Thiamine.A&A practice · 2020Article
- Vitamin D deficiency is associated with disease activity in patients with Crohn's disease.Intestinal research · 2019Article
- Influence of Glucose Dosage in Parenteral Nutrition on Body Thiamine Levels in Rats.International journal of medical sciences · 2019Article
- Vitamins and Minerals in Inflammatory Bowel Disease.Gastroenterology clinics of North America · 2017Review
- A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy.The Journal of international medical research · 2017Article
- Metronidazole-induced encephalopathy in a patient with Crohn's disease.Intestinal research · 2017Article
- Micronutrient deficiencies in inflammatory bowel disease: trivial or crucial?Intestinal research · 2016Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micronutrient deficiencies in Crohn's disease (CD) patients are not uncommon and usually result in a combination of reduced dietary intake, disease-related malabsorption, and a catabolic state. Decreased serum thiamine levels are often reported in patients with CD. Wernicke's encephalopathy (WE) is a severe form of thiamine deficiency that can cause serious neurologic complications. Although WE is known to occur frequently in alcoholics, a number of non-alcoholic causes have also been reported. Here, we report two cases of non-alcoholic WE that developed in two severely malnourished CD patients who were supported by prolonged total parenteral nutrition without thiamine supplementation. These patients complained of sudden-onset ophthalmopathy, cerebellar dysfunction, and confusion. Magnetic resonance imaging allowed definitive diagnosis for WE despite poor sensitivity. The intravenous administration of thiamine alleviated the symptoms of WE dramatically. We emphasize the importance of thiamine supplementation for malnourished patients even if they are not alcoholics, especially in those with CD.
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