Evidence map›Paper›PMID 27175068›Full record

ArticlePatient preference and adherence2016

Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study.

Jean B Nachega, Donald Skinner, Larissa Jennings, Jessica F Magidson, Frederick L Altice, Jessica G Burke, Richard T Lester, Olalekan A Uthman, Amy R Knowlton, Mark F Cotton and 2 more

Open access · goldAbstract read
In one paragraph

Article in Patient preference and adherence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Jean B NachegaDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Medicine, Centre for Infectious Diseases, and ACTG Clinical Trial Unit (CTU)/Family Clinical Research Unit (FAMCRU), Stellenbosch University, Cape Town, South Africa.
Donald SkinnerResearch on Health and Society, Department of Interdisciplinary Health Studies, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Larissa JenningsSocial and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jessica F MagidsonDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Frederick L AlticeDivision of Infectious Diseases, AIDS Program, Yale University School of Medicine, New Haven, CT, USA.
Jessica G BurkeDepartment of Behavioral and Community Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Richard T LesterDepartment of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada.
Olalekan A UthmanWarwick Centre for Applied Health Research and Delivery (WCAHRD), Division of Health Sciences, Warwick Medical School, The University of Warwick, Coventry, UK; Centre for Evidence-Based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Amy R KnowltonDepartment of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mark F CottonDepartment of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Jean R AndersonDepartment of Obstetrics and Gynecology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Gerhard B TheronDepartment of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Bloomberg (United States) · USStellenbosch University · ZAUniversity of Pittsburgh · USWestern Cape Department of Health · ZAJohns Hopkins Medicine · USMassachusetts General Hospital · USUniversity of British Columbia · CA

Funding

Stellenbosch University Clinical Trial Unit, Cape Town, South AfricaUM1AI069521 · NIAID · STELLENBOSCH UNIVERSITY · PI Shaun Barnabas, Anneke Catharina Hesseling · 2012 to 2026
$21.5M
DIRECTLY OBSERVED ANTI RETROVIRAL THERAPY AMONG ACTIVE DR01DA013805 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2000 to 2004
$2.1M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
The MGH Global Psychiatric Clinical Research Training ProgramT32MH093310 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FRICCHIONE, GREGORY L, HENDERSON, DAVID C · 2012 to 2016
$1.3M
Hybrid Effectiveness-Implementation Trial for ART Adherence and Substance Use in HIV Care in South AfricaK23DA041901 · NIDA · UNIV OF MARYLAND, COLLEGE PARK · PI MAGIDSON, JESSICA F · 2016 to 2020
$1.0M
NIAID NIH HHS UM1 AI069521NIDA NIH HHS K23 DA041901NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA013805NIMH NIH HHS T32 MH093310Wellcome Trust
6 · The paper itself

Abstract

objectiveTo examine the acceptability and feasibility of mobile health (mHealth)/short message service (SMS) and community-based directly observed antiretroviral therapy (cDOT) as interventions to improve antiretroviral therapy (ART) adherence for preventing mother-to-child human immunodeficiency virus (HIV) transmission (PMTCT). DESIGN AND

methodsA mixed-method approach was used. Two qualitative focus group discussions with HIV-infected pregnant women (n=20) examined the acceptability and feasibility of two ART adherence interventions for PMTCT: 1) SMS text messaging and 2) patient-nominated cDOT supporters. Additionally, 109 HIV-infected, pregnant South African women (18-30 years old) receiving PMTCT services under single-tablet antiretroviral therapy regimen during pregnancy and breastfeeding and continuing for life ("Option B+") were interviewed about mobile phone access, SMS use, and potential treatment supporters.

settingA community primary care clinic in Cape Town, South Africa.

participantsHIV-infected pregnant women. MAIN OUTCOMES: Acceptability and feasibility of mHealth and cDOT interventions.

resultsAmong the 109 women interviewed, individual mobile phone access and SMS use were high (>90%), and 88.1% of women were interested in receiving SMS ART adherence support messages such as reminders, motivation, and medication updates. Nearly all women (95%) identified at least one person close to them to whom they had disclosed their HIV status and would nominate as a cDOT supporter. Focus group discussions revealed that cDOT supporters and adherence text messages were valued, but some concerns regarding supporter time availability and risk of unintended HIV status disclosure were expressed.

conclusionmHealth and/or cDOT supporter as interventions to improve ART adherence are feasible in this setting. However, safe HIV status disclosure to treatment supporters and confidentiality of text messaging content about HIV and ART were deemed crucial.

Indexed as

AIDSHIVpregnancyshort messaging systemsocial support

Identifiers

PMID27175068
PMCPMC4854240
OpenAlexW2344305309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.