Evidence map›Paper›PMID 27175030›Full record

ArticleHaematologica2016

Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice.

Oliver M Dovey, Bin Chen, Annalisa Mupo, Mathias Friedrich, Carolyn S Grove, Jonathan L Cooper, Benjamin Lee, Ignacio Varela, Yue Huang, George S Vassiliou

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Oliver M DoveyThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK od2@sanger.ac.uk gsv20@sanger.ac.uk.
Bin ChenDepartment of Medical Genetics, School of Basic Medicine, Peking Union Medical College, Beijing, China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China Department of Haematology, Cambridge University Hospitals NHS Trust, UK.
Annalisa MupoThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Mathias FriedrichThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Carolyn S GroveThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia PathWest Division of Clinical Pathology, Queen Elizabeth II Medical Centre, Nedlands, Australia.
Jonathan L CooperThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Benjamin LeeTakeda Pharmaceuticals International, Cambridge, MA, USA.
Ignacio VarelaInstituto de Biomedicina y Biotecnología de Cantabria, Santander, Spain.
Yue HuangDepartment of Medical Genetics, School of Basic Medicine, Peking Union Medical College, Beijing, China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.
George S VassiliouThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK Department of Haematology, Cambridge University Hospitals NHS Trust, UK od2@sanger.ac.uk gsv20@sanger.ac.uk.
Wellcome Sanger Institute · GBPeking Union Medical College Hospital · CNCambridge University Hospitals NHS Foundation Trust · GBInstituto de Biomedicina y Biotecnología de Cantabria · ESQueen Elizabeth II Medical Centre · AUTakeda (United States) · US

Funding

Medical Research Council MC_PC_12009Wellcome TrustWellcome Trust WT095663MA
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Germ-Line MutationAnimalsBenzothiazolesDrug Resistancefms-Like Tyrosine Kinase 3Gene Knock-In TechniquesHumansLeukemia, Myeloid, AcuteMiceNiacinamidePhenylurea CompoundsSorafenibTandem Repeat SequencesTumor Cells, CulturedBenzothiazolesfms-Like Tyrosine Kinase 3NiacinamidePhenylurea CompoundsquizartinibSorafenibacute myeloid leukemiamolecular pharmacologytyrosine kinase inhibitor resistance

Identifiers

PMID27175030
PMCPMC4967582
OpenAlexW2486982244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.