Evidence map›Paper›PMID 27174996›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke.

Douglas J Cook, Cynthia Nguyen, Hyun N Chun, Irene L Llorente, Abraham S Chiu, Michal Machnicki, Thomas I Zarembinski, S Thomas Carmichael

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 2 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 2 syntheses or guidelines pooled it, 194 citations in OpenAlex.

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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Douglas J Cook1 Department of Surgery, Division of Neurosurgery, Kingston General Hospital, Kingston, Canada.
Cynthia Nguyen2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Hyun N Chun2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Irene L Llorente2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Abraham S Chiu2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Michal Machnicki2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
Thomas I Zarembinski3 BioTime, Inc., Alameda, USA.
S Thomas Carmichael2 Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, USA.
University of California, Los Angeles · USKingston General Hospital · CALineage Cell Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is the leading cause of adult disability. Systemic delivery of candidate neural repair therapies is limited by the blood-brain barrier and off-target effects. We tested a bioengineering approach for local depot release of BDNF from the infarct cavity for neural repair in chronic periods after stroke. The brain release levels of a hyaluronic acid hydrogel + BDNF were tested in several stroke models in mouse (strains C57Bl/6, DBA) and non-human primate ( Macaca fascicularis) and tracked with MRI. The behavioral recovery effects of hydrogel + BDNF and the effects on tissue repair outcomes were determined. Hydrogel-delivered BDNF diffuses from the stroke cavity into peri-infarct tissue over 3 weeks in two mouse stroke models, compared with 1 week for direct BDNF injection. Hydrogel delivery of BDNF promotes recovery of motor function. Mapping of motor system connections indicates that hydrogel-BDNF induces axonal sprouting within existing cortical and cortico-striatal systems. Pharmacogenetic studies show that hydrogel-BDNF induces the initial migration of immature neurons into the peri-infarct cortex and their long-term survival. In chronic stroke in the non-human primate, hydrogel-released BDNF can be detected up to 2 cm from the infarct, a distance relevant to human functional recovery in stroke. The hydrogel can be tracked by MRI in mouse and primate.

Indexed as

AnimalsBrain-Derived Neurotrophic FactorDrug Delivery SystemsHydrogel, Polyethylene Glycol DimethacrylateMacaca fascicularisMagnetic Resonance ImagingMiceNeurogenesisRecovery of FunctionStrokeBDNF protein, humanBrain-Derived Neurotrophic FactorHydrogel, Polyethylene Glycol DimethacrylateAxonal sproutingbioengineeringhyaluronanneural repairneurogenesis

Identifiers

PMID27174996
PMCPMC5363479
OpenAlexW2376485786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.