ArticleScience (New York, N.Y.)2016
Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 323 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
323 citing papers in PubMed.
- REM sleep reduction leads to fear overgeneralization via negatively modulating prefrontal theta oscillations.BMC medicine · 2025Trial
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Article
- Review
- Quantifying Cortical Maturational Aspects During Different Vigilance States in Preterm Infants by Advanced EEG Analysis.Journal of sleep research · 2026Article
- Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles.Nature communications · 2026Article
- Energy paradox in REM sleep: balancing supply and consumption in brain metabolism.Communications biology · 2026Article
- A Comprehensive Review of the Gut-Microbiota-Brain Axis in Alzheimer's Disease: From Pathophysiology to Potential Therapies.Pathogens (Basel, Switzerland) · 2026Review
- A septo-entorhinal GABAergic pathway that enables switching between episodic memories.Nature neuroscience · 2026Article
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- Article
- Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition.Phytotherapy research : PTR · 2026Review
- Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience.Nature neuroscience · 2026Article
- Parvalbumin-positive neurons in the medial septum participate in the formation of hippocampal-dependent spatial memory.Nature communications · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Spatial2GWAS: a database for linking spatial transcriptomic regions with GWAS traits.Nucleic acids research · 2026Article
- Study on the Mechanism of Mongolian Medical Warm Acupuncture in Regulating Biological Clock Genes and Improving Sleep in Insomniac Rats.Current medicinal chemistry · 2026Article
- Rapid eye movement sleep displays distinct fractal dynamics between phasic and tonic states.Neuroscience of consciousness · 2026Article
- Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep.Neurology international · 2025Article
263 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Rapid eye movement sleep (REMS) has been linked with spatial and emotional memory consolidation. However, establishing direct causality between neural activity during REMS and memory consolidation has proven difficult because of the transient nature of REMS and significant caveats associated with REMS deprivation techniques. In mice, we optogenetically silenced medial septum γ-aminobutyric acid-releasing (MS(GABA)) neurons, allowing for temporally precise attenuation of the memory-associated theta rhythm during REMS without disturbing sleeping behavior. REMS-specific optogenetic silencing of MS(GABA) neurons selectively during a REMS critical window after learning erased subsequent novel object place recognition and impaired fear-conditioned contextual memory. Silencing MS(GABA) neurons for similar durations outside REMS episodes had no effect on memory. These results demonstrate that MS(GABA) neuronal activity specifically during REMS is required for normal memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.