Evidence map›Paper›PMID 27174937›Full record

ArticleNucleic acids research2016

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.

Shawn M Lyons, Chris Achorn, Nancy L Kedersha, Paul J Anderson, Pavel Ivanov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 250 citations in OpenAlex.

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  15. Y-box binding proteins in immunity and RNA virus infection.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  16. Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  17. Review
  18. Article
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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shawn M LyonsDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Chris AchornDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.
Nancy L KedershaDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Paul J AndersonDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA panderson@rics.bwh.harvard.edu.
Pavel IvanovDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA The Broad Institute of Harvard and M.I.T., Cambridge, MA 02142, USA pivanov@rics.bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Biology of RNA G-quadruplexesR01GM126150 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2019 to 2023
$1.9M
Stress granules and cell signalingR01GM111700 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2014 to 2017
$1.3M
Angiogenin-Induced RNA Cleavage in CancerR01CA168872 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2013 to 2015
$1.1M
G-quadruplex Structures as Targets and Tools in ALSR21NS094918 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2015 to 2016
$488k
Characterization of tiRNA-mediated Translational RepressionF32GM119283 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LYONS, SHAWN M · 2016 to 2017
$115k
NCI NIH HHS R01 CA168872NIGMS NIH HHS F32 GM119283NIGMS NIH HHS R01 GM111700NIGMS NIH HHS R01 GM126150NINDS NIH HHS R21 NS094918
6 · The paper itself

Abstract

Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival. This stress response program relies on a subset tiRNAs that inhibit translation initiation and induce the assembly of stress granules (SGs), cytoplasmic ribonucleoprotein complexes with cytoprotective and pro-survival properties. SG-promoting tiRNAs bear oligoguanine motifs at their 5'-ends, assemble G-quadruplex-like structures and interact with the translational silencer YB-1. We used CRISPR/Cas9-based genetic manipulations and biochemical approaches to examine the role of YB-1 in tiRNA-mediated translational repression and SG assembly. We found that YB-1 directly binds to tiRNAs via its cold shock domain. This interaction is required for packaging of tiRNA-repressed mRNAs into SGs but is dispensable for tiRNA-mediated translational repression. Our studies reveal the functional role of YB-1 in the ANG-mediated stress response program.

Indexed as

Protein BiosynthesisStress, PhysiologicalAmino Acid SequenceArsenitesBase SequenceCell ProliferationCell SurvivalCRISPR-Cas SystemsCytoplasmic GranulesEukaryotic Initiation Factor-4FGene DeletionGene Knockout TechniquesGenetic HeterogeneityHumansMCF-7 CellsModels, MolecularArsenitesEukaryotic Initiation Factor-4FRNA, Guide, CRISPR-Cas SystemsRNA, Transfersodium arseniteSodium CompoundsY-Box-Binding Protein 1YBX1 protein, human

Identifiers

PMID27174937
PMCPMC5001593
OpenAlexW2357230789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.