Evidence map›Paper›PMID 27174923›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016

Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men.

Robert W Morton, Sara Y Oikawa, Christopher G Wavell, Nicole Mazara, Chris McGlory, Joe Quadrilatero, Brittany L Baechler, Steven K Baker, Stuart M Phillips

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 159 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed, 15 pooled it
39.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02139865 nacompletednot on this map

The Effects of Resistance Training Intensity on Muscular Hypertrophy and Strength in Young, Resistance Trained Men

TypeinterventionalSponsorMcMaster UniversityRan2014 to 2016Enrolled50ConditionsSkeletal Muscle Hypertrophy, Muscle WeaknessArms30% 1RM, 80% 1RM
NCT05573321 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Blood Flow Restriction Exercise on Acute Systemic Irisin, Myostatin and Decorin Levels

TypeinterventionalSponsorEge UniversityRan2023 to 2023Enrolled22ConditionsMuscle HypotrophyArmsBFR-RE, HL-RE
3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 15 syntheses or guidelines pooled it, 390 citations in OpenAlex.

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99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Robert W MortonDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Sara Y OikawaDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Christopher G WavellDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Nicole MazaraDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Chris McGloryDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Joe QuadrilateroDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada; and.
Brittany L BaechlerDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada; and.
Steven K BakerDepartment of Neurology, School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada; phillis@mcmaster.ca.
McMaster University · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reported, using a unilateral resistance training (RT) model, that training with high or low loads (mass per repetition) resulted in similar muscle hypertrophy and strength improvements in RT-naïve subjects. Here we aimed to determine whether the same was true in men with previous RT experience using a whole-body RT program and whether postexercise systemic hormone concentrations were related to changes in hypertrophy and strength. Forty-nine resistance-trained men (23 ± 1 yr, mean ± SE) performed 12 wk of whole-body RT. Subjects were randomly allocated into a higher-repetition (HR) group who lifted loads of ∼30-50% of their maximal strength (1RM) for 20-25 repetitions/set (n = 24) or a lower-repetition (LR) group (∼75-90% 1RM, 8-12 repetitions/set, n = 25), with all sets being performed to volitional failure. Skeletal muscle biopsies, strength testing, dual-energy X-ray absorptiometry scans, and acute changes in systemic hormone concentrations were examined pretraining and posttraining. In response to RT, 1RM strength increased for all exercises in both groups (P < 0.01), with only the change in bench press being significantly different between groups (HR, 9 ± 1, vs. LR, 14 ± 1 kg, P = 0.012). Fat- and bone-free (lean) body mass and type I and type II muscle fiber cross-sectional area increased following training (P < 0.01) with no significant differences between groups. No significant correlations between the acute postexercise rise in any purported anabolic hormone and the change in strength or hypertrophy were found. In congruence with our previous work, acute postexercise systemic hormonal rises are not related to or in any way indicative of RT-mediated gains in muscle mass or strength. Our data show that in resistance-trained individuals, load, when exercises are performed to volitional failure, does not dictate hypertrophy or, for the most part, strength gains.

Indexed as

AdultExerciseHormonesHumansHypertrophyMaleMuscle, SkeletalMuscle StrengthResistance TrainingWeight LiftingYoung AdultHormonesanabolismgrowth hormoneloadstrength trainingtestosterone

Identifiers

PMID27174923
PMCPMC4967245
OpenAlexW2351799718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.