Evidence map›Paper›PMID 27174891›Full record

ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2018

Associations of APOE ε4 With Health and Financial Literacy Among Community-Based Older Adults Without Dementia.

Christopher C Stewart, Patricia A Boyle, Bryan D James, Lei Yu, S Duke Han, David A Bennett

Abstract read
In one paragraph

Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. APOE ε4 and Decline in Health and Financial Literacy in Advanced Age.Journal of the American Geriatrics Society · 2026
    Article
  2. Article
  3. Observational
  4. Correlates of healthcare and financial decision making among older adults without dementia.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018
    Article
  5. Religious Orders Study and Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2018
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher C StewartDepartment of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois.
Patricia A BoyleDepartment of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois.
Bryan D JamesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
S Duke HanDepartments of Family Medicine, Neurology, and Psychology, University of Southern California, Los Angeles.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHNEIDER, LON S · 1985 to 2019
$41.0M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Epidemiologic Study of Impaired Decision-Making in Preclinical Alzheimer's DiseasR01AG033678 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BOYLE, PATRICIA A · 2009 to 2025
$7.8M
Neural Correlates of Impaired Financial & Health Care Decision-Making in Old AgeK23AG040625 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAN, DUKE · 2012 to 2016
$820k
Degraded Rationality: Subclinical Neuropathology and Neuroeconomic Behavior in OlR21AG030765 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2007 to 2009
$205k
NIA NIH HHS K23 AG040625NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG033678NIA NIH HHS R01 AG034374NIA NIH HHS R21 AG030765
6 · The paper itself

Abstract

Objectives: Older adults often exhibit low health and financial literacy, but the reasons why remain unclear. One possibility is that those older adults at high risk for developing dementia demonstrate low literacy even in the absence of marked cognitive impairment. We therefore examined associations of health and financial literacy with the APOE ε4 allele, the chief genetic risk factor for Alzheimer's disease, among older adults without dementia. Method: Participants were 487 older adults without dementia enrolled in the Rush Memory and Aging Project (mean age = 83, mean years of education = 15, 77% female, 91% non-Hispanic White). Participants underwent APOE genotyping and assessments of cognition, health literacy, and financial literacy. Health and financial literacy scores were also averaged into a total literacy score. Results: ε4 was associated with lower total and health literacy, with a trend toward an association with lower financial literacy, after adjustment for age, sex, and education. Associations of ε4 with lower total and health literacy persisted after further adjustment for global cognitive function and 5 specific cognitive domains. Discussion: ε4 affects literacy even in the absence of clinical dementia and does so relatively independent of performance on traditional cognitive tests.

Indexed as

Economic StatusHealth LiteracyAged, 80 and overApolipoprotein E4CognitionDementiaFemaleFinancing, PersonalHumansIndependent LivingMaleNeuropsychological TestsApolipoprotein E4

Identifiers

PMID27174891
PMCPMC6283314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.