ArticleScientific reports2016
An investigation into blood microbiota and its potential association with Bacterial Chondronecrosis with Osteomyelitis (BCO) in Broilers.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 75 citations in OpenAlex.
- Microbiome-Targeted Probiotic Strategies for the Prevention and Treatment of Osteomyelitis: A Novel Biological Approach.Probiotics and antimicrobial proteins · 2026Review
- Preliminary Investigation of Cecal Microbiota in Experimental Broilers Reared Under the Aerosol Transmission Lameness Induction Model.Animals : an open access journal from MDPI · 2025Article
- Comparison of Gut Microbiome Profile of Chickens Infected with ThreeMicroorganisms · 2025Article
- Effect of Eimeria spp. and Staphylococcus aureus challenge on cecal microbiome in broilers.Poultry science · 2025Article
- Leveraging Electron Beam-Inactivated Multi-StrainVaccines · 2025Article
- Evaluating the Effectiveness of Probiotic and Multivalent Vaccination Strategies in Mitigating Bacterial Chondronecrosis with Osteomyelitis Lameness Using a Hybrid Challenge Model.Animals : an open access journal from MDPI · 2025Article
- Characterization of blood microbial population in beef calves with clinical signs of sepsis using 16S rRNA gene sequencing.PloS one · 2025Article
- Expanding the use of circulating microbiome in fish: contrast between the gut and blood microbiome ofISME communications · 2025Article
- Effects ofFrontiers in physiology · 2025Article
- Characterizing the blood microbiota in healthy and febrile domestic cats via 16s rRNA sequencing.Scientific reports · 2024Article
- A Review on Pathophysiology, and Molecular Mechanisms of Bacterial Chondronecrosis and Osteomyelitis in Commercial Broilers.Biomolecules · 2023Review
- Body Size Poorly Predicts Host-Associated Microbial Diversity in Wild Birds.Microbiology spectrum · 2023Article
- Article
- Insights into the circulating microbiome of Atlantic and Greenland halibut populations: the role of species-specific and environmental factors.Scientific reports · 2023Article
- Characterization of the Blood Microbiome and Comparison with the Fecal Microbiome in Healthy Dogs and Dogs with Gastrointestinal Disease.Veterinary sciences · 2023Article
- Screening and characterization ofFrontiers in microbiology · 2023Article
- Review on skeletal disorders caused byThe veterinary quarterly · 2022Review
- A Journey into Animal Models of Human Osteomyelitis: A Review.Microorganisms · 2022Review
- Human circulating bacteria and dysbiosis in non-infectious diseases.Frontiers in cellular and infection microbiology · 2022Review
- Morphology of blood microbiota in healthy individuals assessed by light and electron microscopy.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial chondronecrosis with osteomyelitis (BCO) is a common cause of lameness in commercial broiler chickens worldwide. BCO represents substantial production loss and welfare issues of chickens. The bacterial species or communities underlying BCO pathogenesis still remain to be fully characterized. To gain insights on blood microbiota in broilers and its potential association with BCO, blood samples collected from healthy (n = 240) and lame (n = 12) chickens were analyzed by deep sequencing of 16S RNA genes. The chicken blood microbiota were dominated by Proteobacteria (60.58% ± 0.65) followed by Bactroidetes (13.99% ± 0.29), Firmicutes (11.45% ± 0.51), Actinobacteria (10.21% ± 0.37) and Cyanobacteria (1.96% ± 0.21) that constituted 98.18% (± 0.22) of the whole phyla. The bacterial communities consist of 30-40 OTUs in the blood of broiler chickens, regardless of ages and other environmental or host conditions, and the blood microbiomes of BCO chickens were largely distinct from those of healthy chickens. In addition, Linear discriminant analysis (LDA) effect size (LEfSe) method revealed that Staphylococcus, Granulicatella, and Microbacterium were significantly enriched in BCO chickens as compared to healthy chickens. The results from this study have significant implications in understanding blood microbiota present in broiler chickens and its potential role in BCO pathogenesis.
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