ArticleInternational journal of epidemiology2016
Loss of confidence in vaccines following media reports of infant deaths after hepatitis B vaccination in China.
Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Birth and death notification via mobile devices: a mixed methods systematic review.The Cochrane database of systematic reviews · 2021Pooled it
- Profit considerations in vaccine safety-related events in China.Expert review of vaccines · 2019Pooled it
- Willingness to accept the HBV vaccine and related factors: Administering the vaccination attitudes examination scale to Urban Vietnamese adults.PLOS global public health · 2026Article
- Case-control study of risk factors for abscess development following hepatitis B vaccination in children in Timor-Leste, 2024.PloS one · 2026Article
- Adverse event reporting following immunization of hepatitis B vaccine: A 13-year review.Human vaccines & immunotherapeutics · 2024Article
- How to address vaccine hesitancy? Lessons from National Hepatitis B Immunization Program in China.Frontiers in public health · 2024Review
- Assessing the impact of the 2018 Changchun Changsheng vaccine incident on childhood vaccination in China.Communications medicine · 2023Article
- Analysis of death cases in Shenyang City, China, for immunization adverse event surveillance, 2009-2021.Human vaccines & immunotherapeutics · 2023Article
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- Reforms in China's Vaccine Administration-From the Perspective of New Governance Approach.International journal of environmental research and public health · 2023Review
- Deliberation, context, emotion and trust - understanding the dynamics of adults' COVID-19 vaccination decisions in Germany.BMC public health · 2023Article
- Hepatitis B eradication: vaccine as a key player.American journal of translational research · 2023Review
- Caregivers' understanding of childhood influenza vaccination during the epidemic in China. A mixed-methods study.Frontiers in public health · 2023Article
- Analysis of deaths following yeast-derived hepatitis B vaccination of infants, China, January 2013 to December 2020.Frontiers in public health · 2023Article
- Assessing vaccine hesitancy using the WHO scale for caregivers of children under 3 years old in China.Frontiers in public health · 2023Article
- Using an extended protection motivation theory to explain vaccine hesitancy: a cross-sectional study among Chinese adults.Human vaccines & immunotherapeutics · 2022Article
- Racial and incident discrepancies in news media reporting of sudden unexpected infant death (SUID).Injury epidemiology · 2022Article
- Media portrayal of vaccine: a content analysis of Vietnam online news about a pentavalent vaccine in the Expanded Program of Immunization.Wellcome open research · 2022Article
- The impact of negative emotional reactions on parental vaccine hesitancy after the 2018 vaccine event in China: A cross-sectional survey.Human vaccines & immunotherapeutics · 2021Article
- A New Strategy for Cervical Cancer Prevention Among Chinese Women: How Much Do They Know and How Do They React Toward the HPV Immunization?Journal of cancer education : the official journal of the American Association for Cancer Education · 2021Article
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25 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChina reduced hepatitis B virus (HBV) infection by 90% among children under 5 years old with safe and effective hepatitis B vaccines (HepB). In December 2013, this success was threatened by widespread media reports of infant deaths following HepB administration. Seventeen deaths and one case of anaphylactic shock following HBV vaccination had been reported.
methodsWe conducted a telephone survey to measure parental confidence in HepB in eleven provinces at four points in time; reviewed maternal HBV status and use of HepB for newborns in birth hospitals in eight provinces before and after the event; and monitored coverage with hepatitis B vaccine and other programme vaccines in ten provinces.
resultsHepB from the implicated company was suspended during the investigation, which showed that the deaths were not caused by HepB vaccination. Before the event, 85% respondents regarded domestic vaccines as safe, decreasing to 26.7% during the event. During the height of the crisis, 30% of parents reported being hesitant to vaccinate and 18.4% reported they would refuse HepB. Use of HepB in the monitored provinces decreased by 18.6%, from 53 653 doses the week before the event to 43 688 doses during the week that Biokangtai HepB was suspended. Use of HepB within the first day of life decreased by 10% among infants born to HBsAg-negative mothers, and by 6% among infants born to HBsAg-positive mothers. Vaccine refusal and HepB birth dose rates returned to baseline within 2 months; confidence increased, but remained below baseline.
conclusionsThe HBV vaccine event resulted in the suspension of a safe vaccine, which was associated with a decline of parental confidence, and refusal of vaccination. Suspension of a vaccine can lead to loss of confidence that is difficult to recover. Timely and credible investigation, accompanied by proactive outreach to stakeholders and the media, may help mitigate negative impact of future coincidental adverse events following immunization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.