Evidence map›Paper›PMID 27174780›Full record

ArticleEnvironmental research2016

Associations of individual characteristics and lifestyle factors with metabolism of di-2-ethylhexyl phthalate in NHANES 2001-2012.

Lusine Yaghjyan, Nils P Carlsson, Gabriela L Ghita, Su-Hsin Chang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children of South Korea.Environmental science and pollution research international · 2021
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lusine YaghjyanDepartment of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd., Gainesville, FL, USA. Electronic address: lyaghjyan@ufl.edu.
Nils P CarlssonDivision of Public Health Sciences, Department of Surgery, School of Medicine, Washington University in St. Louis, 660 S. Euclid Ave., St. Louis, MO, USA. Electronic address: carlssonn@wudosis.wustl.edu.
Gabriela L GhitaDepartment of Biostatistics, College of Public Health and Health Professions and College of Medicine, University of Florida, 2004 Mowry Rd., Gainesville, FL, USA. Electronic address: glghita0429@ufl.edu.
Su-Hsin ChangDivision of Public Health Sciences, Department of Surgery, School of Medicine, Washington University in St. Louis, 660 S. Euclid Ave., St. Louis, MO, USA. Electronic address: changsh@wudosis.wustl.edu.
University of Florida · USWashington University in St. Louis · US

Funding

Worksite Policies and neighborhood Influences on Obesity and Cancer RiskU54CA155496 · NCI · WASHINGTON UNIVERSITY · PI COLDITZ, GRAHAM A. · 2011 to 2016
$9.0M
OBESITY, COMORBIDITIES, AND ECONOMIC EVALUATIONS OF SURGICAL TREATMENTS OF OBESITK01HS022330 · AHRQ · WASHINGTON UNIVERSITY · PI CHANG, SU-HSIN · 2013 to 2016
$505k
AHRQ HHS K01 HS022330NCI NIH HHS U54 CA155496
6 · The paper itself

Abstract

backgroundPrevious studies suggest that a higher ratio of primary to secondary metabolites of di-2-ethylhexyl phthalate (DEHP), reflective of a slower DEHP conversion rate, is associated with a greater physiologic effect. We examined associations of several individual characteristics and lifestyle factors with the ratio of mono-2-ethylhexyl phthalate to mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHP:MEHHP) and %MEHP (the ratio of MEHP to the sum of the secondary metabolites).

methodsWe used the data from the National Health and Nutrition Examination Survey, 2001-2012. The study included adults with BMI<30 and no diabetes. Pregnant women were excluded. We examined associations of age, race, gender, Body Mass Index, smoking, alcohol and caffeine consumption, medication use, cancer history, and menopausal status and postmenopausal hormone use (in women) with MEHP:MEHHP and %MEHP using multivariable linear regression. The values for %MEHP were log-transformed in the analysis.

resultsIn multivariable analysis, non-Caucasian individuals had higher %MEHP (non-Hispanic Blacks: β=0.114, 95% Confidence interval [CI]: 0.050, 0.177; Hispanic: β=0.089, 95% CI: 0.024, 0.154; other race: β=0.126, 95% CI: 0.033, 0.219). Age was inversely associated with MEHP:MEHHP (β=-0.001, 95% CI: -0.002, -0.001) and %MEHP (β=-0.006, 95% CI: -0.008, -0.004). Overweight individuals had lower MEHP: MEHHP and lower %MEHP (β=-0.035, 95% CI: 0.062, -0.008 and β=-0.104, 95% CI: -0.162, -0.046, respectively). Alcohol consumption was inversely associated with %MEHP among men (p-trend=0.03).

conclusionsIndividual and lifestyle characteristics are associated with differences in DEHP metabolism. Understanding underlying biological mechanisms could help to identify individuals at a greater risk of adverse effects from DEHP exposure.

Indexed as

Environmental ExposureLife StyleSocioeconomic FactorsAdolescentAdultAgedAged, 80 and overDiethylhexyl PhthalateEnvironmental PollutantsFemaleHumansLinear ModelsMaleMiddle AgedNutrition SurveysUnited StatesDiethylhexyl PhthalateEnvironmental PollutantsEndocrine disruptorsLifestylePhthalate exposureRisk factors

Identifiers

PMID27174780
PMCPMC5536839
OpenAlexW2371154767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.