ArticleBrazilian journal of otorhinolaryngology
Effects of ozone therapy on facial nerve regeneration.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Experimental evidence for the beneficial effects of low-concentration ozone.Medical gas research · 2027Review
- Effects of repeated exposure to ozonated water on hair fibre structure and integrity: Part I.International journal of cosmetic science · 2026Article
- Effects of ozone and methylprednisolone treatment in facial paralysis: An experimental study.Turkish journal of physical medicine and rehabilitation · 2025Article
- Investigation of the Effects of the Timing of Decompression and Topical Mitomycin-C Application on Nerve Regeneration in a Rat Model of Bell's Palsy.Turkish archives of otorhinolaryngology · 2025Article
- Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy.Nanomaterials (Basel, Switzerland) · 2025Review
- The role of antioxidants in facial nerve injury.Frontiers in molecular biosciences · 2025Review
- Comparison of the Effects of Perineural and Intraperitoneal Ozone Therapy on Nerve Healing in an Experimental Sciatic Nerve Injury Model.Medicina (Kaunas, Lithuania) · 2024Article
- Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action.International journal of molecular sciences · 2024Review
- Ozone Disc Nucleolysis for Cervical Intervertebral Disc Herniation: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Establishment of a facial nerve trunk crush injury model and evaluation of facial nerve self-healing in rats.Brain and behavior · 2023Article
- Ozone in Chemotherapy-Induced Peripheral Neuropathy-Current State of Art, Possibilities, and Perspectives.International journal of molecular sciences · 2023Review
- Evaluation of targeted oxidative stress induced by oxygen-ozoneRedox report : communications in free radical research · 2022Article
- Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice.Biomedicines · 2022Review
- Effects of Topical Treatment of Foot Rot in Sheep Using Ozonated Olive Ointment.Journal of veterinary research · 2021Article
- Efficacy of exenatide, ozone, and methyl prednisolone for the recovery of infraorbital nerve paresthesia after injury in rats.Dental research journal · 2021Article
- The effect of insulin-like growth factor 1 on the recovery of facial nerve function in a guinea pig model of facial palsy.The journal of physiological sciences : JPS · 2020Article
- Air pollution by NOScientific reports · 2020Article
- Efficacy and Safety of Percutaneous Ozone Injection Around Gasserian Ganglion for the Treatment of Trigeminal Neuralgia: A Multicenter Retrospective Study.Journal of pain research · 2020Article
- Recent Findings on the Effects of Pharmacological Agents on the Nerve Regeneration after Peripheral Nerve Injury.Current neuropharmacology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOzone may promote moderate oxidative stress, which increases antioxidant endogenous systems. There are a number of antioxidants that have been investigated therapeutically for improving peripheral nerve regeneration. However, no previous studies have reported the effect of ozone therapy on facial nerve regeneration.
objectiveWe aimed to evaluate the effect of ozone therapy on facial nerve regeneration.
methodsFourteen Wistar albino rats were randomly divided into two groups with experimental nerve crush injuries: a control group, which received saline treatment post-crush, and an experimental group, which received ozone treatment. All animals underwent surgery in which the left facial nerve was exposed and crushed. Treatment with saline or ozone began on the day of the nerve crush. Left facial nerve stimulation thresholds were measured before crush, immediately after crush, and after 30 days. After measuring nerve stimulation thresholds at 30 days post-injury, the crushed facial nerve was excised. All specimens were studied using light and electron microscopy.
resultsPost-crushing, the ozone-treated group had lower stimulation thresholds than the saline group. Although this did not achieve statistical significance, it is indicative of greater functional improvement in the ozone group. Significant differences were found in vascular congestion, macrovacuolization, and myelin thickness between the ozone and control groups. Significant differences were also found in axonal degeneration and myelin ultrastructure between the two groups.
conclusionWe found that ozone therapy exerted beneficial effect on the regeneration of crushed facial nerves in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.