ArticleScientific reports2016
An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Current trends in RNA virus detection through metatranscriptome sequencing data.FEBS open bio · 2023Review
- Opportunities and Limitations of Molecular Methods for Studying Bat-Associated Pathogens.Microorganisms · 2022Review
- Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells.Mobile DNA · 2022Article
- A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability.Journal of virology · 2021Article
- No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses.Virology journal · 2020Article
- Detection and characterization of a novel bat-borne coronavirus in Singapore using multiple molecular approaches.The Journal of general virology · 2019Article
- Sperm RNA code programmes the metabolic health of offspring.Nature reviews. Endocrinology · 2019Review
- The evolution, distribution and diversity of endogenous circoviral elements in vertebrate genomes.Virus research · 2019Article
- Functional lability of RNA-dependent RNA polymerases in animals.PLoS genetics · 2019Article
- Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral VectorFrontiers in genetics · 2019Article
- Systematic estimation of insertion dates of endogenous bornavirus-like elements in vesper bats.The Journal of veterinary medical science · 2018Article
- Divergent bornaviruses from Australian carpet pythons with neurological disease date the origin of extant Bornaviridae prior to the end-Cretaceous extinction.PLoS pathogens · 2018Article
- An expressed, endogenous Nodavirus-like element captured by a retrotransposon in the genome of the plant parasitic nematode Bursaphelenchus xylophilus.Scientific reports · 2016Article
- Establishment and characterization of a cell line derived from Eptesicus nilssonii.The Journal of veterinary medical science · 2016Article
- Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians.PLoS pathogens · 2016Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous bornavirus-like L (EBLL) elements are inheritable sequences derived from ancient bornavirus L genes that encode a viral RNA-dependent RNA polymerase (RdRp) in many eukaryotic genomes. Here, we demonstrate that bats of the genus Eptesicus have preserved for more than 11.8 million years an EBLL element named eEBLL-1, which has an intact open reading frame of 1,718 codons. The eEBLL-1 coding sequence revealed that functional motifs essential for mononegaviral RdRp activity are well conserved in the EBLL-1 genes. Genetic analyses showed that natural selection operated on eEBLL-1 during the evolution of Eptesicus. Notably, we detected efficient transcription of eEBLL-1 in tissues from Eptesicus bats. To the best of our knowledge, this study is the first report showing that the eukaryotic genome has gained a riboviral polymerase gene from an ancient virus that has the potential to encode a functional RdRp.
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