ArticleScientific reports2016
Pilot study of adrenal steroid hormones in hair as an indicator of chronic mental and physical stress.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Open-label placebos reduce hair cortisol concentrations and psychological distress - a randomized controlled trial.Scientific reports · 2026Trial
- The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.European journal of psychotraumatology · 2025Trial
- Mixed evidence for stress effects on cortisol-testosterone coupling in Syrian refugee and Jordanian non-refugee adolescents.Psychoneuroendocrinology · 2026Article
- Teachers' acute cardiovascular response to observed classroom disruptions and resulting chronic endocrine stress. Analysis of dynamic effects with global assessments for state space grids.Frontiers in physiology · 2026Article
- Analysing and quantifying chronic stress-associated endogenous steroids in hair samples.Drug testing and analysis · 2024Article
- Predicting stress levels using physiological data: Real-time stress prediction models utilizing wearable devices.AIMS neuroscience · 2024Review
- On the complex relationship between resilience and hair cortisol levels in adolescence despite parental physical abuse: a fourth wave of resilience research.Frontiers in psychiatry · 2024Article
- Higher Levels of Stress-Related Hair Steroid Hormones Are Associated with the Increased SCORE2 Risk Prediction Algorithm in Apparently Healthy Women.Journal of cardiovascular development and disease · 2022Article
- Association between workaholism, vital exhaustion, and hair cortisol concentrations among teachers: A longitudinal study testing the moderation effect of neuroticism.Frontiers in psychology · 2022Article
- A Review of Biophysiological and Biochemical Indicators of Stress for Connected and Preventive Healthcare.Diagnostics (Basel, Switzerland) · 2021Review
- The Stress of Caring-Resilience and HPA-Axis Activity in Hair Samples of Youth Residential Caregivers.Frontiers in psychiatry · 2020Article
- Measuring wool cortisol and progesterone levels in breeding maiden Australian merino sheep (Ovis aries).PloS one · 2019Article
- Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study.Acta diabetologica · 2018Article
- Persistent LHPA Activation in German Individuals Raised in an Overprotective Parental Behavior.Scientific reports · 2017Article
- Circumcision does not alter long-term glucocorticoids accumulation or psychological effects associated with trauma- and stressor-related disorders.Translational psychiatry · 2017Article
- Elevated hair cortisol concentrations in recently fled asylum seekers in comparison to permanently settled immigrants and non-immigrants.Translational psychiatry · 2017Article
- Emotional and psychological trauma in refugees arriving in Germany in 2015.Molecular psychiatry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, the quantitative analysis of moderators affecting the function of the hypothalamus-pituitary-adrenal (HPA)-axis in health and sickness is still unreliable. This is, in particular, due to physiological factors such as pulsatile ultradian and circadian glucocorticoid secretion as well as to methodological limitations of the current techniques for steroid hormone determination. Based on this background, the determination of long-term hair steroid concentrations is an important methodological improvement allowing for the quantitative analysis of chronic HPA axis-activation. In order to determine the relationship between chronic mental and physical stress and a chronic activation of the HPA axis, we performed a cross-sectional pilot-study with 40 healthy students and examined the relationships between physical activity, mental burden(s), subjective stress perceptions, depressiveness, anxiety, physical complaints, sense of coherence, resilience, and the long-term integrated steroid hormone levels in hair. The results showed that the concentrations of cortisol, cortisone, and dehydroepiandrosterone in hair were significantly correlated to mental (p = 0.034) and physical stress (p = 0.001) as well as to subjective stress perception (p = 0.006). We conclude that steroid concentrations in hair are decisive predictors for an increase in the long-term-HPA axis activity. Moreover, this biomarker is suitable for capturing the stresslevel after burdening events and physical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.