ArticleScientific reports2016
Alterations in gray matter volume due to unilateral hearing loss.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Current Understanding of Hearing Loss in Sporadic Vestibular Schwannomas: A Systematic Review.Frontiers in oncology · 2021Pooled it
- Gray matter declines with age and hearing loss, but is partially maintained in tinnitus.Scientific reports · 2020Trial
- Executive Functioning in Single-Sided Deafness: A Pediatric Comparison with Temporal Lobe Epilepsy.Journal of clinical medicine · 2026Article
- Disrupted structural covariance network in presbycusis patients: evidence from a large sample mri-based morphometric study.Frontiers in aging neuroscience · 2026Article
- Dementia and hearing loss: from risk to mechanisms and management.Frontiers in dementia · 2026Review
- Socially-Based Emotion Dysregulation Among Hearing-Impaired Adolescents: An Event-Related Potential Study.Brain and behavior · 2025Article
- Somatosensory cross-modal activation and changes in cortical somatosensory evoked potential responses in single-sided deafness: an EEG study.Frontiers in neuroscience · 2025Article
- Brain structural alterations in vestibular schwannoma beyond tinnitus and hearing loss.Brain communications · 2025Article
- Dehydration-associated cerebral hypoperfusion in sudden sensorineural hearing loss: an arterial spin labeling-based preliminary study.Frontiers in neurology · 2025Article
- A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment.Antioxidants (Basel, Switzerland) · 2024Review
- Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review).International journal of molecular medicine · 2024Review
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- A Novel Multi-Model High Spatial Resolution Method for Analysis of DCE MRI Data: Insights from Vestibular Schwannoma Responses to Antiangiogenic Therapy in Type II Neurofibromatosis.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The characteristics of brain structural remodeling in patients with unilateral vestibular schwannoma.Journal of neuro-oncology · 2023Article
- Vascular Factors in Patients with Midlife Sensorineural Hearing Loss and the Progression to Mild Cognitive Impairment.Medicina (Kaunas, Lithuania) · 2023Article
- Preoperative Visual Impairment in Vestibular Schwannoma Patients: An Overlooked Entity of Developing World.Asian journal of neurosurgery · 2022Article
- Insight into postural control in unilateral sensorineural hearing loss and vestibular hypofunction.PloS one · 2022Article
- Cognitive decline in acoustic neuroma patients: An investigation based on resting-state functional magnetic resonance imaging and voxel-based morphometry.Frontiers in psychiatry · 2022Article
- Intrinsic brain activity reorganization contributes to long-term compensation of higher-order hearing abilities in single-sided deafness.Frontiers in neuroscience · 2022Article
- Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although extensive research on neural plasticity resulting from hearing deprivation has been conducted, the direct influence of compromised audition on the auditory cortex and the potential impact of long durations of incomplete sensory stimulation on the adult cortex are still not fully understood. In this study, using voxel-based morphometry, we evaluated gray matter (GM) volume changes that may be associated with reduced hearing ability and the duration of hearing impairment in 42 unilateral hearing loss (UHL) patients with acoustic neuromas compared to 24 normal controls. We found significant GM volume increases in the somatosensory and motor systems and GM volume decreases in the auditory (i.e., Heschl's gyrus) and visual systems (i.e., the calcarine cortex) in UHL patients. The GM volume decreases in the primary auditory cortex (i.e., superior temporal gyrus and Heschl's gyrus) correlated with reduced hearing ability. Meanwhile, the GM volume decreases in structures involving high-level cognitive control functions (i.e., dorsolateral prefrontal cortex and anterior cingulate cortex) correlated positively with hearing loss duration. Our findings demonstrated that the severity and duration of UHL may contribute to the dissociated morphology of auditory and high-level neural structures, providing insight into the brain's plasticity related to chronic, persistent partial sensory loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.