Evidence map›Paper›PMID 27174445›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2016

Breastfeeding and maternal alcohol use: Prevalence and effects on child outcomes and fetal alcohol spectrum disorders.

Philip A May, Julie M Hasken, Jason Blankenship, Anna-Susan Marais, Belinda Joubert, Marise Cloete, Marlene M de Vries, Ronel Barnard, Isobel Botha, Sumien Roux and 11 more

Abstract read
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
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  4. Effects of an Alcohol-Related Harm Prevention Program among Out-of-School Female Adolescents.International journal of environmental research and public health · 2021
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  13. Associations of maternal alcohol and non-prescribed substance use with early child growth.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 2 countries.

Philip A MayThe University of North Carolina at Chapel Hill, Nutrition Research Institute, United States; The University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, United States; Stellenbosch University, Faculty of Medicine and Health Sciences, South Africa. Electronic address: philip_may@unc.edu.
Julie M HaskenThe University of North Carolina at Chapel Hill, Nutrition Research Institute, United States.
Jason BlankenshipThe University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, United States.
Anna-Susan MaraisStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Belinda JoubertStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Marise CloeteStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Marlene M de VriesStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Ronel BarnardStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Isobel BothaStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Sumien RouxStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Cate DomsStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
J Phillip GossageThe University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, United States.
Wendy O KalbergThe University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, United States.
David BuckleyThe University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, United States.
Luther K RobinsonState University of New York, Buffalo, Department of Pediatrics, United States.
Colleen M AdnamsUniversity of Cape Town, Department of Psychiatry and Mental Health, South Africa.
Melanie A ManningStanford University School of Medicine, Departments of Pathology and Pediatrics, United States.
Charles D H ParryStellenbosch University, Faculty of Medicine and Health Sciences, South Africa; Medical Research Council of South Africa, Alcohol, Tobacco & Other Drug Research Unit, South Africa.
H Eugene HoymeSanford Research, University of South Dakota Sanford School of Medicine, Department of Pediatrics, United States.
Barbara TabachnickCalifornia State University, Northridge, United States.
Soraya SeedatStellenbosch University, Faculty of Medicine and Health Sciences, South Africa.
Stellenbosch University · ZAUniversity of New Mexico · USUniversity of North Carolina at Chapel Hill · USCalifornia State University, Northridge · USSouth African Medical Research Council · ZAStanford University · USUniversity at Buffalo, State University of New York · USUniversity of Cape Town · ZAUniversity of South Dakota · US

Funding

TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIESU01AA011685 · NIAAA · UNIVERSITY OF NEW MEXICO · PI MAY, PHILIP ALAN · 2002 to 2008
$8.9M
TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIESR01AA011685 · NIAAA · UNIVERSITY OF NEW MEXICO · PI MAY, PHILIP ALAN · 1998 to 2001
$3.1M
NIAAA NIH HHS R01 AA011685NIAAA NIH HHS U01 AA011685
6 · The paper itself

Abstract

objectiveDetermine any effects that maternal alcohol consumption during the breastfeeding period has on child outcomes.

methodsPopulation-based samples of children with fetal alcohol spectrum disorders (FASD), normally-developing children, and their mothers were analyzed for differences in child outcomes.

resultsNinety percent (90%) of mothers breastfed for an average of 19.9 months. Of mothers who drank postpartum and breastfed (MDPB), 47% breastfed for 12 months or more. In case control analyses, children of MDPB were significantly lighter, had lower verbal IQ scores, and more anomalies in comparisons controlling for prenatal alcohol exposure and final FASD diagnosis. Utilizing a stepwise logistic regression model adjusting for nine confounders of prenatal drinking and other maternal risks, MDPB were 6.4 times more likely to have a child with FASD than breastfeeding mothers who abstained from alcohol while breastfeeding.

conclusionsAlcohol use during the period of breastfeeding was found to significantly compromise a child's development.

Indexed as

Breast FeedingAdultAlcohol DrinkingChildChild DevelopmentEthanolFemaleFetal Alcohol Spectrum DisordersHumansIntelligence TestsMaternal ExposureMothersPregnancyPrenatal Exposure Delayed EffectsPrevalenceSouth AfricaEthanolAlcoholBreastfeedingChild health and developmentFetal alcohol spectrum disorders (FASD)Pregnancy

Identifiers

PMID27174445
PMCPMC4987236
OpenAlexW2345802571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.