Evidence map›Paper›PMID 27174145›Full record

ArticleThe Journal of pediatrics2016

Feeding at the Breast and Expressed Milk Feeding: Associations with Otitis Media and Diarrhea in Infants.

Kelly M Boone, Sheela R Geraghty, Sarah A Keim

Open access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Breastfeeding Measurement - Considerations When Measuring Exclusive Breastfeeding.Journal of human lactation : official journal of International Lactation Consultant Association · 2025
    Article
  10. Human milkFrontiers in nutrition · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Association of Infant Feeding Methods and Excess Weight from Birth to Age 6.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2021
    Article
  18. Article
  19. Infant Feeding Practices During the First Postnatal Year and Risk of Asthma and Allergic Disease During the First 6 Years of Life.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kelly M BooneCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH. Electronic address: kelly.boone@nationwidechildrens.org.
Sheela R GeraghtyCincinnati Children's Center for Breastfeeding Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Sarah A KeimCenter for Biobehavioral Health, The Research Institute at Nationwide Children's Hospital, Columbus, OH; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH.
Nationwide Children's Hospital · USCincinnati Children's Hospital Medical Center · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Role of Environmental Chemicals on Lactation OutcomesK23ES014691 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI GERAGHTY, SHEELA RATH · 2006 to 2010
$702k
NCATS NIH HHS UL1 TR001070NIEHS NIH HHS K23 ES014691
6 · The paper itself

Abstract

objectiveTo examine the associations of substance fed and mode of breast milk delivery with occurrence of otitis media and diarrhea in the first year of life. STUDY

designAt 12 months postpartum, women (n = 813; 62% response) completed a questionnaire that assessed sociodemographics, infant occurrence of otitis media and diarrhea, and the timing of starting/stopping feeding at the breast, expressed milk, and formula. Women who intended to "bottle feed" exclusively were not recruited. Logistic and negative binomial regressions were conducted in the full sample (n = 491) and no-formula (n = 106) and bottle-only (n = 49) subsamples.

resultsLonger duration of expressed milk feeding was associated with increased odds of experiencing otitis media (6-month OR [OR6-month] 2.15, 95% CI 1.01-4.55) in the no-formula subsample. Longer durations of breast milk feeding (OR6-month 0.70, 95% CI 0.54-0.92; 6-month incidence rate ratio [IRR6-month] 0.74, 95% CI 0.63-0.91), and feeding at the breast (OR6-month 0.70, 95% CI 0.54-0.89; IRR6-month 0.74, 95% CI 0.63-0.88) were associated with less diarrhea, and longer formula feeding duration was associated with increased risk of diarrhea (IRR6-month 1.34, 95% CI 1.13-1.54) in the full sample.

conclusionSubstance fed and mode of breast milk delivery have different contributions to infant health depending on the health outcome of interest. Feeding at the breast may be advantageous compared with expressed milk feeding for reducing the risk of otitis media, and breast milk feeding compared with formula may reduce the risk of diarrhea.

Indexed as

Bottle FeedingBreast FeedingInfant FormulaMilk, HumanCohort StudiesDiarrheaFemaleHumansIncidenceInfantInfant, NewbornMaleOtitis Mediabreastfeedingbreast milk expressionnegative binomial regression

Identifiers

PMID27174145
PMCPMC9554740
OpenAlexW2345841572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.